2-[Hydroxy(icosoxy)phosphoryl]oxyethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[Hydroxy(icosoxy)phosphoryl]oxyethyl-trimethylazanium
• 化学式: C25H55NO4P+
• 分子量: 464.7
• InChiKey: GBVXCWIFVJOILK-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  31
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel alkyl phospholipid derivatives and uses thereof
  申请人：Zentaris GmbH

  公开号：EP1800684A1

  公开（公告）日：2007-06-27

  The present invention provides novel alkyl phospholipid derivatives that are useful for treating various diseases including tumors and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular fungi, protozoa, bacteria and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies, in particular for the treatment of leishmaniasis, trypanosomiasis and/or malaria.

  本发明提供了新型烷基磷脂衍生物，可用于治疗包括肿瘤和/或哺乳动物（尤其是人类）中由微生物，特别是真菌、原虫、细菌和/或病毒引起的各种疾病，这些烷基磷脂可作为单一药物或结合疗法的一部分，特别是用于治疗利什曼病、锥虫病和/或疟疾。
• Methods of treating protozoal diseases
  申请人：Max-Planck-Gessellschaft zur Forderung der Wissenschaften e. V.

  公开号：US20010008885A1

  公开（公告）日：2001-07-19

  The invention concerns a new pharmaceutical agent for oral or topical administration in the treatment of protozoal diseases, in particular of leishmaniasis, which contains as the active substance one or several compounds having the general formula I 1 in which R 1 is a saturated or monounsaturated or polyunsaturated hydrocarbon residue with 12 to 20 C atoms and R 2 , R 3 and R 4 denote independently of one another hydrogen, a C 1 -C 5 alkyl group, a C 3 -C 6 cycloalkyl group or a C 1 -C 5 hydroxyalkyl group whereby two of the residues R 2 , R 3 and R 4 can together form a C 2 -C 5 alkylene group which, if desired, can be substituted with an —O—, —S— or NR 5 group, in which R 5 is hydrogen, a C 1 -C 5 alkyl group, a C 3 -C 6 cycloalkyl group or a C 1 -C 5 hydroxyalkyl group as well as, if desired the usual pharmaceutical auxiliary, diluting, carrier or/and filling substances.

  本发明涉及一种用于口服或局部用药治疗原生动物疾病，特别是利什曼病的新药剂，它含有一种或几种通式为 I 的化合物作为活性物质。 1 其中 R 1 是饱和的或单不饱和的或多不饱和的烃残基，其结构式为 12 至 20 C 原子，而 R 2 , R 3 和 R 4 分别表示氢、C 1 -C 5 烷基、C 3 -C 6 环烷基或 C 1 -C 5 羟烷基，其中两个残基 R 2 , R 3 和 R 4 可共同形成一个 C 2 -C 5 烯基，如果需要，可被-O-、-S- 或 NR 5 基团取代，其中 R 5 是氢、C 1 -C 5 烷基 3 -C 6 环烷基或 C 1 -C 5 6 环烷基或 C 1 -C 5 羟烷基，以及（如需要）常用的药用助剂、稀释剂、载体或/和填充物。
• NOVEL ALKYL PHOSPHOLIPID DERIVATIVES WITH REDUCED CYTOTOXICITY AND USES THEREOF
  申请人：PERRISSOUD Daniel

  公开号：US20070167408A1

  公开（公告）日：2007-07-19

  The present invention provides novel alkyl phospholipid derivatives with reduced cytotoxicity that are useful for treating various diseases and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular bacteria, fungi, protozoa and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies and can also be used for the treatment of tumors.
• US6254879B1
  申请人：——

  公开号：US6254879B1

  公开（公告）日：2001-07-03
• US6506393B2
  申请人：——

  公开号：US6506393B2

  公开（公告）日：2003-01-14