4-methyl-6-[5-(6-methyl-pyridin-2-yl)-1H-[1,2,3]triazol-4-yl]-4H-benzo[1,4]oxazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 4-methyl-6-[5-(6-methyl-pyridin-2-yl)-1H-[1,2,3]triazol-4-yl]-4H-benzo[1,4]oxazin-3-one
• 英文别名: 4-methyl-6-[5-(6-methylpyridin-2-yl)-2H-triazol-4-yl]-1,4-benzoxazin-3-one
• 化学式: C₁₇H₁₅N₅O₂
• 分子量: 321.338
• InChiKey: LXOQCVPSFUZFET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  84
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] BENZOXAZINE AND BENZOXAZINONE SUBSTITUTED TRIAZOLES<br/>[FR] TRIAZOLES A SUBSTITUTION BENZOXAZINE ET BENZOXAZINONE
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2003097639A1

  公开（公告）日：2003-11-27

  This invention relates to benzoxazine and benzoxazinone substituted triazoles which are inhibitors of the transforming growth factor, ('TGF')-ß signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ('ALK')-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  该发明涉及取代三唑的苯并噁嗪和苯并噁嗪酮，它们是转化生长因子（TGF）-ß信号通路的抑制剂，特别是通过TGF-β类型I或类活素激酶（ALK）-5受体对smad2或smad3的磷酸化，以及它们的制备方法和在医学上的应用，特别是在治疗和预防通过这一途径介导的疾病状态。
• Benzoxazine and benzoxazinone substituted triazoles
  申请人：Gellibert Jeanne Francoise

  公开号：US20050165011A1

  公开（公告）日：2005-07-28

  This invention relates to benzoxazine and benzoxazinone substituted triazoles which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β, type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及苯并噁嗪和苯并噁嗪酮取代的三唑类化合物，它们是转化生长因子（"TGF"）-β 信号通路的抑制剂，特别是 TGF-β、I 型或类活化因子激酶（"ALK"）-5 受体对 smad2 或 smad3 磷酸化的抑制剂，本发明还涉及它们的制备方法及其在医学中的用途，特别是在治疗和预防由该通路介导的疾病中的用途。
• BENZOXAZINE AND BENZOXAZINONE SUBSTITUTED TRIAZOLES
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1506191A1

  公开（公告）日：2005-02-16