(1Z)-N'-hydroxypropanimidamide hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1Z)-N'-hydroxypropanimidamide hydrochloride
• 英文别名: N'-hydroxypropanimidamide;hydrochloride
• 化学式: C₃H₈N₂O*ClH
• 分子量: 124.57
• InChiKey: MEFFHUDYLHPCRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.56
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  58.6
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[(2,2-Dimethylmorpholin-4-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid 、 (1Z)-N'-hydroxypropanimidamide hydrochloride 生成 (2,2-Dimethylmorpholin-4-yl) {3-(3-ethyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}methanone
  参考文献：
  名称：

  HETEROARYL-SUBSTITUTED PIPERIDINES

  摘要：

  本发明涉及新型杂环芳基取代哌啶，其制备过程，其用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物，特别是心血管疾病和肿瘤疾病。

  公开号：

  US20090306139A1

文献信息

• [EN] PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE<br/>[FR] PIPÉRIDINYLPYRAZOLOPYRIMIDINONES ET LEUR UTILISATION
  申请人：BAYER PHARMA AG

  公开号：WO2016071216A1

  公开（公告）日：2016-05-12

  The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

  本申请涉及新型取代哌啶基吡唑吡嘧啶酮，以及它们的制备方法，这些化合物可单独或组合使用于治疗和/或预防疾病的方法中，特别是用于治疗和/或预防患有或不患有基础遗传或获得性止血障碍的患者的急性和复发性出血，其中出血与从重经期出血、产后出血、出血性休克、出血性膀胱炎、胃肠道出血、创伤、手术、移植、中风、肝脏疾病、遗传性血管性水肿、鼻血、以及血液积聚后的滑膜炎和软骨损伤等一组疾病或医疗干预有关。
• [EN] HYDROXYISOXAZOLINES AND DERIVATIVES THEREOF<br/>[FR] HYDROXYISOXAZOLINES ET LEURS DÉRIVÉS
  申请人：BAYER AG

  公开号：WO2019122393A1

  公开（公告）日：2019-06-27

  The present disclosure relates to the use of hydroxyisoxazolines and derivatives thereof as fungicide. It also relates to new hydroxyisoxazolines derivatives, their use as fungicide and compositions comprising thereof.

  本公开涉及将羟基异噁唑啉及其衍生物用作杀菌剂。它还涉及新的羟基异噁唑啉衍生物，它们作为杀菌剂的用途以及包含它们的组合物。
• HETEROARYL-SUBSTITUTED PIPERIDINES
  申请人：Heimbach Dirk

  公开号：US20090306139A1

  公开（公告）日：2009-12-10

  The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumour diseases.

  本发明涉及新型杂环芳基取代哌啶，其制备过程，其用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物，特别是心血管疾病和肿瘤疾病。
• [EN] AMIDO-SUBSTITUTED PYRIDYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPESVIRUSES<br/>[FR] COMPOSÉS PYRIDYLE AMIDO-SUBSTITUÉS ET LEURS MÉTHODES D'UTILISATION POUR LE TRAITEMENT DES VIRUS DE L'HERPÈS
  申请人：MERCK SHARP & DOHME

  公开号：WO2022146755A1

  公开（公告）日：2022-07-07

  The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

  本发明涉及公式（I）的新型酰胺取代杂环化合物及其药学上可接受的盐，其中R1、R2、R3、R4、R7和R8如本文所定义。本发明还涉及包含至少一种酰胺取代杂环化合物的组合物，并且使用酰胺取代杂环化合物治疗或预防患者的疱疹病毒感染的方法。
• Heteroaryl-substituted piperidines
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US08119663B2

  公开（公告）日：2012-02-21

  The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumor diseases.

  本发明涉及新型杂环芳基取代哌啶，其制备过程，以及它们用于治疗和/或预防疾病的用途，以及用于制备治疗和/或预防疾病的药物，特别是心血管疾病和肿瘤疾病。