1,1,1-triisopropyl-3,3,3-trimethyldisiloxane

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1,1,1-triisopropyl-3,3,3-trimethyldisiloxane
• 英文别名: Trimethyl-tri(propan-2-yl)silyloxysilane；trimethyl-tri(propan-2-yl)silyloxysilane
• 化学式: C₁₂H₃₀OSi₂
• 分子量: 246.541
• InChiKey: ZJTCSJXNIPQYMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.01
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  三异丙基氯硅烷 在 氨 、 水 、 sodium 作用下， 以 四氢呋喃 、 正戊烷 为溶剂， 生成 1,1,1-triisopropyl-3,3,3-trimethyldisiloxane
  参考文献：
  名称：

  三异丙基硅烷醇：一种新型的用于脱卤化氢的相转移催化剂

  摘要：

  已开发出一种新型的固液相转移催化剂三异丙基硅烷醇（TIPSOH），该催化剂通过硅烷醇/硅烷酸酯系统使KOH甚至可以将伯烷基卤化物定量地转化为烯烃，从而避免了醚和醇的副产物。已经证明了其在芥子气类似物和环境污染物的解毒中的潜在应用。

  DOI：

  10.1016/0040-4039(96)00330-9

文献信息

• An Efficient Catalytic Approach for the Synthesis of Unsymmetrical Siloxanes
  作者：Grzegorz Hreczycho

  DOI：10.1002/ejic.201402904

  日期：2015.1

  expanding the variety of catalytic methods for siloxane bond formation is explored. Alkoxysilanes react with methylallylsilanes in the presence of scandium(III) trifluoromethanesulfonate to yield disiloxanes and isobutene. The reaction proceeds through one-pot hydrolysis/O-silylation of alkoxysilanes with allylsilanes (via silanol intermediates) under mild conditions. Unsaturated siloxane products are used

  探索了扩大硅氧烷键形成催化方法种类的潜力。在三氟甲磺酸钪 (III) 存在下，烷氧基硅烷与甲基烯丙基硅烷反应生成二硅氧烷和异丁烯。该反应通过烷氧基硅烷与烯丙基硅烷（通过硅烷醇中间体）在温和条件下的一锅水解/O-甲硅烷基化进行。不饱和硅氧烷产物用作通过催化氢化硅烷化反应进一步官能化的底物。
• A Highly Effective Route to Si−O−Si Moieties through <i>O</i> ‐Silylation of Silanols and Polyhedral Oligomeric Silsesquioxane Silanols with Disilazanes
  作者：Krzysztof Kuciński、Grzegorz Hreczycho

  DOI：10.1002/cssc.201802757

  日期：2019.3.7

  A simple and highly practical catalyst‐free O‐silylation of silanols with commercially available disilazanes has been developed under mild conditions. In the case of polyhedral oligomeric silsesquioxane (POSS) silanols and some other silanols, it was necessary to use catalytic amounts of inexpensive Bi(OTf)3 as additional catalyst. This efficient chlorine‐free protocol involves the synthesis of a wide

  一个简单且高度实用的无催化剂Ø硅醇基与市售二硅氮烷-silylation已经温和的条件下开发的。对于多面体低聚倍半硅氧烷（POSS）硅烷醇和其他一些硅烷醇，必须使用催化量的廉价Bi（OTf）3作为附加催化剂。这种有效的无氯方案涉及多种重要有机硅衍生物的合成，例如不对称二硅氧烷和功能化的倍半硅氧烷。
• Silylation of silanols with vinylsilanes catalyzed by a ruthenium complex
  作者：Bogdan Marciniec、Piotr Pawluć、Grzegorz Hreczycho、Anna Macina、Martyna Madalska

  DOI：10.1016/j.tetlet.2007.12.091

  日期：2008.2

  A new ruthenium complex-catalyzed O-silylation of silanols with vinylsilanes leading to siloxane bond formation with the evolution of ethylene is described. A maximum conversion of silanol is reached using an excess of vinylsilane to also yield the product of the homo-coupling of the latter. Under the optimum conditions, when vinylsilane with at least one ethoxy substituent is used, the reaction gives exclusively unsymmetrical siloxanes. (c) 2007 Published by Elsevier Ltd.
• O-Metalation of silanols and POSS silanols over Amberlyst-15 catalyst: A facile route to unsymmetrical siloxanes, borasiloxanes and germasiloxanes
  作者：Krzysztof Kuciński、Grzegorz Hreczycho

  DOI：10.1016/j.ica.2019.03.025

  日期：2019.5

  A simple and highly practical Amberlyst-catalyzed direct O-metalation of silanols, POSS silanols and alkoxy-silanes under mild conditions is proposed. This protocol can be applied to the synthesis of a wide range of important organosilicon derivatives such as siloxanes, germasiloxanes, borasiloxanes and functionalized silses-quioxanes. It is worth noting that Amberlyst-15 can be reused for further experiments and its catalytic activity in this process is well-preserved for several recycling steps.
• Triisopropylsilanol: A new type of phase transfer catalyst for dehydrohalogenation
  作者：John A. Soderquist、Jaime Vaquer、Michael J. Diaz、Anil M. Rane、Frederick G. Bordwell、Shizhong Zhang

  DOI：10.1016/0040-4039(96)00330-9

  日期：1996.4

  A new solid-liquid phase transfer catalyst, trisopropylsilanol (TIPSOH), has been developed which, through the silanol/silanoate system, allows KOH to quantitatively convert even primary alkyl halides to alkenes avoiding both ether and alcohol by-products. Its potential application in the detoxification of mustard gas analogues and environmental pollutants has been demonstrated.

  已开发出一种新型的固液相转移催化剂三异丙基硅烷醇（TIPSOH），该催化剂通过硅烷醇/硅烷酸酯系统使KOH甚至可以将伯烷基卤化物定量地转化为烯烃，从而避免了醚和醇的副产物。已经证明了其在芥子气类似物和环境污染物的解毒中的潜在应用。