[(E)-1,3-dihydroxyoctadec-4-en-2-yl]-trimethylazanium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [(E)-1,3-dihydroxyoctadec-4-en-2-yl]-trimethylazanium
• 化学式: C21H44NO2+
• 分子量: 342.6
• InChiKey: XOKJULOVXVISRP-ISLYRVAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• SPHINGOSINE KINASE INHIBITORS AND METHODS OF THEIR USE
  申请人：Smith D. Charles

  公开号：US20070032531A1

  公开（公告）日：2007-02-08

  The invention relates to compounds, pharmaceutical compositions thereof, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease,

  这项发明涉及化合物、其药物组合物以及抑制鞘氨醇激酶并治疗或预防过度增殖性疾病、炎症性疾病或血管生成性疾病的方法。
• SPHINGOSINE KINASE INHIBITORS
  申请人：Smith D. Charles

  公开号：US20060287317A1

  公开（公告）日：2006-12-21

  The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.

  这项发明涉及替代金刚烷化合物，其药物组成部分，其制备过程，以及抑制神经鞘氨醇激酶、治疗或预防过度增殖性疾病、炎症性疾病或血管生成性疾病的方法。
• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Protein and peptide delivery to mammalian cells in vitro
  申请人：Monahan D. Sean

  公开号：US20060034909A1

  公开（公告）日：2006-02-16

  Compositions and methods for delivery of proteins and peptides to mammalian cells in vitro are described. Specifically, polypeptide-surfactant complexes formed from noncovalent hydrophobation of polypeptides and reversible hydrophobic modification of polypeptides are described. The compositions can be used to delivery positively charged, negatively charged and charge neutral polypeptides to cells.

  本文描述了用于体外哺乳动物细胞中蛋白质和肽的传递的组合物和方法。具体来说，本文描述了由多肽的非共价疏水化和可逆疏水修饰形成的多肽-表面活性剂复合物。该组合物可用于向细胞传递带正电荷、负电荷和中性电荷的多肽。
• Sphingolipids
  申请人：——

  公开号：US20030133904A1

  公开（公告）日：2003-07-17

  The invention relates to compounds of the general formula (I), as defined, and to pharmaceutical compositions containing them. The compounds of formula (T) are inhibitors of various lipid-related enzymes. They can be used in reducing accumulation of sphingolipids and thus in the treatment of lipid storage diseases. The compounds of formula (I) can also be used for the treatment of cancerous diseases and for killing of wild type and drug-resistant cancer cells.

  本发明涉及通式（I）所定义的化合物，以及含有它们的药物组合物。式（T）化合物是各种与脂类相关的酶的抑制剂。它们可用于减少鞘脂的积累，从而用于治疗脂质储存病。式（I）化合物也可用于治疗癌症和杀死野生型和耐药癌细胞。