(3-chloro-phenyl)-(3-thiophen-3-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: (3-chloro-phenyl)-(3-thiophen-3-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-amine
• 英文别名: N-(3-chlorophenyl)-3-thiophen-3-ylpyrazolo[1,5-a]pyrimidin-5-amine
• 化学式: C₁₆H₁₁ClN₄S
• 分子量: 326.809
• InChiKey: WNJMEKPAAJAXTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME
  申请人：Ince Stuart

  公开号：US20080039455A1

  公开（公告）日：2008-02-14

  The invention relates to pyrazolopyrimidines according to the general formula (I): and salts thereof, to pharmaceutical compositions comprising said pyrazolopyrimidines and to a method of preparing said pyrazolopyrimidines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment or prophylaxis of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth

  本发明涉及一种通式(I)的吡唑吡咯啉化合物及其盐，涉及包含该吡唑吡咯啉化合物的制药组合物，以及制备该吡唑吡咯啉化合物的方法，以及将其用于制造用于治疗或预防异常血管生长病或伴随异常血管生长病的药物组合物的用途。
• Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1873157A1

  公开（公告）日：2008-01-02

  The invention relates to pyrazolopyrimidines according to the general formula (I) : and salts thereof, to pharmaceutical compositions comprising said pyrazolopyrimidines and to a method of preparing said pyrazolopyrimidines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment or prophylaxis of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth.

  本发明涉及通式（I）的吡唑并嘧啶类化合物： 及其盐类，涉及包含所述吡唑嘧啶的药物组合物，涉及制备所述吡唑嘧啶的方法，以及使用所述吡唑嘧啶制造药物组合物，用于治疗或预防血管生长失调疾病或伴随血管生长失调的疾病。
• PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME.
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2049539A1

  公开（公告）日：2009-04-22
• [EN] PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME.<br/>[FR] PYRAZOLOPYRIMIDINES ET LEURS SELS, COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT, PROCÉDÉS DE PRÉPARATION DE CELLES-CI ET LEURS UTILISATIONS.
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2007147647A1

  公开（公告）日：2007-12-27

  [EN] The invention relates to pyrazolopyrimidines according to the general formula (I) : and salts thereof, to pharmaceutical compositions comprising said pyrazolopyrimidines and to a method of preparing said pyrazolopyrimidines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment or prophylaxis of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth
  [FR] L'invention concerne des pyrazolopyrimidines représentés par la formule générale (I) : et des sels de celles-ci, des compositions pharmaceutiques comprenant lesdites pyrazolopyrimidines et un procédé de préparation desdites pyrazolopyrimidines ainsi que leur utilisation dans la fabrication d'une composition pharmaceutique pour le traitement ou la prophylaxie de maladies de croissance vasculaire dysrégulée ou de maladies qui s'accompagnent d'une croissance vasculaire dysrégulée.