3,4-diamino-naphthalene-1-sulfonic acid sodium salt

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3,4-diamino-naphthalene-1-sulfonic acid sodium salt
• 英文别名: Sodium 3,4-diaminonaphthalene-1-sulfonate；sodium;3,4-diaminonaphthalene-1-sulfonate
• 化学式: C₁₀H₉N₂O₃S*Na
• 分子量: 260.249
• InChiKey: KFZIPBHIOBJKFA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.09
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  congo red 在 palladium on activated charcoal 一水合肼 作用下， 以 乙醇 为溶剂， 反应 20.0h， 以76%的产率得到3,4-diamino-naphthalene-1-sulfonic acid sodium salt
  参考文献：
  名称：

  Congo red analogues as potential anti-prion agents

  摘要：

  'Transmissible Spongiform Encephalopathies' (TSE) are a group of degenerative, progressive and fatal disorders of CNS which affect both humans and animals, characterised by a long incubation time. The pathogenetic mechanism in TSE is the conversion of normal prion protein (PrP(sen)) to an altered protease resistant isoform (PrP(res)) that accumulates in amyloid deposits into the brain; therefore, PrP(res) is the primary target for therapeutic strategies. The discovery that the sulphonated azo dye Congo red (CR) is able to inhibit the replications of TSE agents and the accumulation of PrP(res) in animals and in scrapie infected mouse neuroblastoma cells induced us to designe molecules structurally related to CR (1a-f, 2f,g). The compounds were tested in vitro to evaluate their interaction with 263K PrP(res). Six of the tested compounds were found to interact with PrP(res) molecules and to over-stabilise the PrP(res) aggregates, as CR does. However, none of them induced the reversion of PrP(res) to PrP(sen).

  DOI：

  10.1016/s0014-827x(03)00151-4

文献信息

• Catalytic Activity of Cobalt Nanoparticles for Dye and 4-Nitro Phenol Degradation: A Kinetic and Mechanistic Study
  作者：Mohammad Naved Khan、Ommer Bashir、Tabrez Alam Khan、Shaeel Ahmed Al-Thabaiti、Zaheer Khan

  DOI：10.1002/kin.21089

  日期：2017.6

  The reaction follows fractional‐order kinetics with respect to [NaBH4] for Congo red degradation. The activation energies were found to be 24 and 74 kJ mol−1, respectively, for Congo red and 4‐NP catalyzed reactions. The AgNPs has no catalytic activity toward Congo red. The degradation pathway mechanism with observed kinetics has been proposed and discussed, which follows the following rate law:

  准备了十六烷基三甲基溴化铵（CTAB）封端的纳米级α-钴氢氧化物（CoNPs），可在室温下在无阳光存在下去除刚果红。紫外/可见光谱表明，CoNPs和NaBH 4对刚果红和4-硝基苯酚（4-NP）的降解没有催化作用，而CoNPs则是少量NaBH 4的有效催化剂。催化反应具有诱导期，随后是自动加速，这取决于[NaBH 4 ]。对于刚果红降解，反应遵循关于[NaBH 4 ]的分数阶动力学。发现活化能为24和74kJ mol -1分别用于刚果红和4-NP催化反应 AgNP对刚果红没有催化活性。已经提出并讨论了具有观察到的动力学的降解途径机理，该机理遵循以下速率定律：
• A porous trimetallic Au@Pd@Ru nanoparticle system: synthesis, characterisation and efficient dye degradation and removal
  作者：Anupam Sahoo、Suman Kumar Tripathy、Niranjan Dehury、Srikanta Patra

  DOI：10.1039/c5ta03959b

  日期：——

  Treatment of azo dye-based waste water using new trimetallic porous Au@Pd@RuNPs and solid waste dolochar is described.

  使用新的三金属多孔Au@Pd@RuNPs和固体废弃物dolochar处理偶氮染料废水。