1-(3-triethylammonio)propyl-1,4,7,10,13-penta-azacyclopentadecane | 272118-30-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(3-triethylammonio)propyl-1,4,7,10,13-penta-azacyclopentadecane
• 英文别名: R6DD3Era9E；triethyl-[3-(1,4,7,10,13-pentazacyclopentadec-1-yl)propyl]azanium;bromide
• CAS: 272118-30-6
• 化学式: Br*C₁₉H₄₅N₆
• 分子量: 437.51
• InChiKey: PYICWIQFPTYBFZ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.07
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N¹,N⁴,N⁷,N¹⁰,N¹³-pentatosyl-1,4,7,10,13-penta-azacyclopentadecane 在 硫酸 作用下， 以 水 为溶剂， 反应 12.0h， 生成 1-(3-triethylammonio)propyl-1,4,7,10,13-penta-azacyclopentadecane
  参考文献：
  名称：

  Synthesis ofN-quaternary ammonium [3H] and [99mTc]polyazamacrocycles, potential radiotracers for cartilage imaging

  摘要：

  The [H-3] and [Tc-99m] synthesis of three new compounds, N-[3-(pyridinio)propyl] cyclam (NPPC), N-[3-(triethylammonium)propyl] cyclam (NTPC) and N-[3-(triethylammonium)propyl]-15ane-N5 (NTP 15-5), potential tracers for cartilage, is reported. NPPC and NTPC were labelled with tritium on the ethyl group of cyclam with a specific radioactivity of 89 MBq/mmol. The [Tc-99m]-labelling of the three quaternary ammonium chelates was realized with a high specific activity in the range 20-25 MBq/mu mol.

  DOI：

  10.1002/(sici)1099-1344(200005)43:6<585::aid-jlcr343>3.0.co;2-h

文献信息

• Synthesis ofN-quaternary ammonium [3H] and [99mTc]polyazamacrocycles, potential radiotracers for cartilage imaging
  作者：Colette Nicolas、Mich�le Borel、Jean-Claude Maurizis、Nadine Gallais、Maryse Rapp、Monique Ollier、Michel Verny、Jean-Claude Madelmont

  DOI：10.1002/(sici)1099-1344(200005)43:6<585::aid-jlcr343>3.0.co;2-h

  日期：2000.5

  The [H-3] and [Tc-99m] synthesis of three new compounds, N-[3-(pyridinio)propyl] cyclam (NPPC), N-[3-(triethylammonium)propyl] cyclam (NTPC) and N-[3-(triethylammonium)propyl]-15ane-N5 (NTP 15-5), potential tracers for cartilage, is reported. NPPC and NTPC were labelled with tritium on the ethyl group of cyclam with a specific radioactivity of 89 MBq/mmol. The [Tc-99m]-labelling of the three quaternary ammonium chelates was realized with a high specific activity in the range 20-25 MBq/mu mol.