diethyl (1-(1-hydroxybutan-2-yl)aziridin-2-yl)phosphonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: diethyl (1-(1-hydroxybutan-2-yl)aziridin-2-yl)phosphonate
• 英文别名: (2R)-2-(2-diethoxyphosphorylaziridin-1-yl)butan-1-ol
• 化学式: C₁₀H₂₂NO₄P
• 分子量: 251.263
• InChiKey: NLRLYGKBWJBYCI-KPPDAEKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙酰亚磷酸二乙酯 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 反应 48.0h， 生成 diethyl (1-(1-hydroxybutan-2-yl)aziridin-2-yl)phosphonate
  参考文献：
  名称：

  Synthesis of 2-aziridinyl phosphonates by modified Gabriel–Cromwell reaction and their antibacterial activities

  摘要：

  A set of new aziridinyl phosphonates (4a-g) were synthesized by using the Gabriel-Cromwell reaction and its modified version developed in this study and their structures confirmed by HRMS, IR. and NMR spectra. All the compounds were screened for their antibacterial activity. They all showed comparable moderate to good growth inhibitory activity in reference to ampicillin and streptomycin. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.03.037

文献信息

• Synthesis of 2-aziridinyl phosphonates by modified Gabriel–Cromwell reaction and their antibacterial activities
  作者：Özdemir Doğan、Hakan Babiz、Ayşe Gül Gözen、Songül Budak

  DOI：10.1016/j.ejmech.2011.03.037

  日期：2011.6

  A set of new aziridinyl phosphonates (4a-g) were synthesized by using the Gabriel-Cromwell reaction and its modified version developed in this study and their structures confirmed by HRMS, IR. and NMR spectra. All the compounds were screened for their antibacterial activity. They all showed comparable moderate to good growth inhibitory activity in reference to ampicillin and streptomycin. (C) 2011 Elsevier Masson SAS. All rights reserved.