ethyl N-benziisothiazolylacetamidate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: ethyl N-benziisothiazolylacetamidate
• 英文别名: ethyl N-(1,2-benzothiazol-3-yl)ethanimidate
• 化学式: C₁₁H₁₂N₂OS
• 分子量: 220.295
• InChiKey: JWBYDJPHSSJABT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  62.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氨基-1,2-苯并异噻唑 、 乙基乙酰亚胺盐酸盐 以 乙醇 为溶剂， 反应 24.0h， 以80%的产率得到ethyl N-benziisothiazolylacetamidate
  参考文献：
  名称：

  Synthesis and preliminary pharmacological study of new amidinobenzisothiazoles

  摘要：

  Some new N-(1,2-benzisothiazol-3-yl)amidines were synthesized and tested for antiinflammatory, antipyretic, analgesic and spasmolytic activities in comparison with indomethacin and papaverine respectively. The synthesis of the new compounds has been described. All the amidinobenzisothiazoles showed remarkable analgesic action and an interesting antiphlogistic action, while only one drug displayed a certain antipyretic activity. As regards spasmolytic activity, 3 compounds out of 6 demonstrated a papaverine-like effect.

  DOI：

  10.1016/0223-5234(93)90051-f

文献信息

• Synthesis and preliminary pharmacological study of new amidinobenzisothiazoles
  作者：P Vicini、L Amoretti、V Ballabeni、E Barocelli、M Chiavarini

  DOI：10.1016/0223-5234(93)90051-f

  日期：1993.1

  Some new N-(1,2-benzisothiazol-3-yl)amidines were synthesized and tested for antiinflammatory, antipyretic, analgesic and spasmolytic activities in comparison with indomethacin and papaverine respectively. The synthesis of the new compounds has been described. All the amidinobenzisothiazoles showed remarkable analgesic action and an interesting antiphlogistic action, while only one drug displayed a certain antipyretic activity. As regards spasmolytic activity, 3 compounds out of 6 demonstrated a papaverine-like effect.