8-Bromo-[1,6]naphthyridine-2-carboxylic acid (1-phenyl-ethyl)-amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-Bromo-[1,6]naphthyridine-2-carboxylic acid (1-phenyl-ethyl)-amide
• 英文别名: 8-bromo-N-(1-phenylethyl)-1,6-naphthyridine-2-carboxamide
• 化学式: C₁₇H₁₄BrN₃O
• 分子量: 356.222
• InChiKey: ACAYUFUIPRLKTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS
  申请人：Merck Patent GmbH

  公开号：US20160016951A1

  公开（公告）日：2016-01-21

  The present invention relates to naphthyridine and isoquinoline compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of CDK8/19, and for the treatment of CDK8/19-related disorders.

  本发明涉及萘啶和异喹啉化合物，以及由此组成的药物可接受的组合物，作为CDK8/19的抑制剂，用于治疗与CDK8/19相关疾病。
• NOVEL NAPHTHRYIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS
  申请人：Merck Patent GmbH

  公开号：EP3169678A1

  公开（公告）日：2017-05-24
• [EN] NOVEL NAPHTHRYIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS<br/>[FR] NOUVELLES NAPHTYRIDINES ET ISOQUINOLÉINES ET LEUR UTILISATION À TITRE D'INHIBITEURS DE CDK8/19
  申请人：MERCK PATENT GMBH

  公开号：WO2016009076A1

  公开（公告）日：2016-01-21

  The present invention relates to naphthyridine and isoquinoline compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of CDK8/19, and for the treatment of CDK8/19-related disorders.