(R/S)-4-(3-phenylbutyl)morpholine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R/S)-4-(3-phenylbutyl)morpholine
• 英文别名: 4-(3-phenyl-butyl)-morpholine；4-(3-Phenyl-butyl)-morpholin；4-(3-Phenylbutyl)morpholine
• 化学式: C₁₄H₂₁NO
• 分子量: 219.327
• InChiKey: NLMUTNTVABGYTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(3-phenylbut-3-en-1-yl)morpholine 在 乙醇 、 镍 作用下， 生成 (R/S)-4-(3-phenylbutyl)morpholine
  参考文献：
  名称：

  The Reaction of Formaldehyde and Secondary Amines with Some Olefins

  摘要：

  DOI：

  10.1021/ja01622a057

文献信息

• [EN] MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE<br/>[FR] MODULATEURS D'INDOLAMINE 2,3-DIOXYGÉNASE
  申请人：GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO 2) LTD

  公开号：WO2017051354A1

  公开（公告）日：2017-03-30

  Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of HIV; including the prevention of the progression of AIDS and general immunosuppression.

  提供了这些化合物及其药用盐，它们的药物组合物，它们的制备方法，以及它们在预防和/或治疗HIV方面的使用方法；包括预防AIDS的进展和一般免疫抑制。
• One-Pot Synthesis of Secondary and Tertiary Amines by Carbonylative Hydroaminomethylation of Alkenes Catalyzed by Di(μ-chloro)bis(η4-1,5-cyclooctadiene)dirhodium
  作者：Thorsten Rische、Peter Eilbracht

  DOI：10.1055/s-1997-1338

  日期：1997.11

  Secondary and tertiary amines are selectively prepared with high yields by the reaction of alkenes with primary or secondary amines, carbon monoxide and hydrogen in the presence of [Rh(cod)Cl]2 as catalyst via a one-pot hydroformylation - amine condensation - reduction sequence.

  次级和三级胺通过在[Rh(cod)Cl]2催化剂存在下，烯烃与一级或二级胺、一氧化碳和氢气反应，经一步法羰基合成-胺缩合-还原序列高效选择性制备。
• BICYCLIC DIAMINES AS JANUS KINASE INHIBITORS
  申请人：Guerin David Joseph

  公开号：US20130225577A1

  公开（公告）日：2013-08-29

  The instant invention provides compounds of formula I which are Jak inhibitors, and as such are useful for the treatment of Jak-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

  本发明提供了公式I的化合物，这些化合物是Jak抑制剂，因此对于治疗Jak介导的疾病如类风湿性关节炎、哮喘、慢性阻塞性肺疾病和癌症有用。
• Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines
  作者：Daniela Rossi、Marta Rui、Marcello Di Giacomo、Dirk Schepmann、Bernhard Wünsch、Stefania Monteleone、Klaus R. Liedl、Simona Collina

  DOI：10.1016/j.bmc.2016.10.005

  日期：2017.1

  Sigma Receptor (SR) modulators are involved in different signal transduction pathways, representing important pharmacological/therapeutic tools in several pathological conditions, such as neurodegenerative diseases and cancers. To this purpose, numerous compounds have been developed in order to target selectively one of the two subtypes (S1R and S2R) as chemotherapeutic agent. However, experiments have also shown that ligands which are able to bind both SR subtypes can be useful for the diagnosis and/or the treatment of cancers. Therefore, the discovery of compounds with good affinity towards both S1R and S2R ('pan-modulators') is also of great interest and still represents a challenge up to now. For this reason, we synthesized novel arylalkylamines with the aim to obtain compounds with S1R and S2R affinity in the nM range and, by modeling quantitative structure-activity relationships (QSARs), we identified the essential structural features to obtain promising pan-compounds. (C) 2016 Elsevier Ltd. All rights reserved.
• MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE
  申请人：GlaxoSmithKline Intellectual Property (No. 2) Limited

  公开号：EP3353167B1

  公开（公告）日：2020-06-24