((decahydroisoquinolinyl)tricyclo[3.3.1.1^3,7]dec-1-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: ((decahydroisoquinolinyl)tricyclo[3.3.1.1^3,7]dec-1-yl)methanone
• 英文别名: 2-(Adamantane-1-carbonyl)-decahydroisoquinoline；3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl(1-adamantyl)methanone
• 化学式: C₂₀H₃₁NO
• 分子量: 301.472
• InChiKey: XRLSYGXRAVSIMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  十氢异喹啉 、 1-金刚烷甲酸 在 N,N'-羰基二咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 ((decahydroisoquinolinyl)tricyclo[3.3.1.1^3,7]dec-1-yl)methanone
  参考文献：
  名称：

  Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors

  摘要：

  A series of adamantyl amide 11 beta-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11 beta-HSD1 over 11 beta-HSD2 and possess excellent cellular potency in human and murine 11 beta-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.057

文献信息

• COSMETIC COMPOSITIONS WITH TRICYCLODECANE AMIDES
  申请人：Conopco, Inc., d/b/a UNILEVER

  公开号：US20160008249A1

  公开（公告）日：2016-01-14

  The invention is directed to a cosmetic composition and the precursor thereof. The composition has solid agent and liquid agent, both of which are cosmetic benefit ingredients. The solubility of solid agents in liquid agents in the inventive compositions is enhanced in the presence of a tricyclodecane amide.

  该发明涉及一种化妆品组合物及其前体。该组合物具有固体剂和液体剂，两者均为化妆品益处成分。在创新组合物中，固体剂在液体剂中的溶解性在三环十二碳酰胺的存在下得到增强。
• [EN] PHOTOPROTECTIVE COMPOSITIONS WITH TRICYCLODECANE AMIDES<br/>[FR] COMPOSITIONS DE PHOTOPROTECTION CONTENANT DES TRICYCLODÉCANES AMIDES
  申请人：UNILEVER PLC

  公开号：WO2014139965A1

  公开（公告）日：2014-09-18

  A personal care photoprotective composition is provided having a UV-A and UV-B sunscreen in conjunction with a tricyclodecane amide. The tricyclodecane amide functions to boost UV-A, UV-B and SPF performance when the personal care composition is applied to skin or hair of the human body.

  提供一种个人护理光保护组合物，其中包含UV-A和UV-B防晒剂，以及三环十二烷酰胺。当该个人护理组合物被涂抹在人体皮肤或头发上时，三环十二烷酰胺能够增强UV-A、UV-B和SPF的性能。
• [EN] PROCESS OF MAKING ADAMANTANAMIDES<br/>[FR] PROCÉDÉ DE FABRICATION D'ADAMANTANAMIDES
  申请人：UNILEVER PLC

  公开号：WO2015086428A1

  公开（公告）日：2015-06-18

  An effective process of making adamantanamide, which process is fast, does not the use of organic solvents or labor-intensive isolation or purification of the product, by removal of organic solvent or by-products, and has improved yield and purity.

  一种制备金刚烷酰胺的有效方法，该方法快速，不使用有机溶剂或劳动密集型的产品分离或纯化，通过去除有机溶剂或副产物，具有改善的产量和纯度。
• [EN] PROLONGED DELIVERY OF CERTAIN FRAGRANCE COMPONENTS FROM PERSONAL CARE COMPOSITIONS<br/>[FR] LIBÉRATION PROLONGÉE DE CERTAINS COMPOSANTS DE FRAGRANCE DE COMPOSITIONS DE SOINS PERSONNELS
  申请人：UNILEVER PLC

  公开号：WO2014139952A3

  公开（公告）日：2014-12-04
• PROCESS OF MAKING ADAMANTANAMIDES
  申请人：Unilever PLC, a company registered in England and Wales under company no. 41424 of

  公开号：EP3080086B1

  公开（公告）日：2017-07-05