Natrium-n-Octylsulfat-(3)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: Natrium-n-Octylsulfat-(3)
• 英文别名: Sodium;octan-3-yl sulfate
• 化学式: C₈H₁₇O₄S*Na
• 分子量: 232.276
• InChiKey: QVXIOGITPAYFSZ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.17
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Natrium-n-Octylsulfat-(3) 在 Rhodococcus ruber DSM 44541 alkylsulfatase 、 iron(II) chloride 作用下， 以 水 为溶剂， 反应 0.08h， 生成 (S)-(+)-3-辛醇 、 sodium;[(3R)-octan-3-yl] sulfate 、 sodium;[(3S)-octan-3-yl] sulfate
  参考文献：
  名称：

  Selectivity-enhancement in enantioselective hydrolysis of sec-alkyl sulfates by an alkylsulfatase from Rhodococcus ruber DSM 44541

  摘要：

  The Enantioselectivity of the biohydrolysis of sec-alkyl sulfate esters using a bacterial alkylsulfatase from Rhodococcus ruber DSM 44541 was dramatically enhanced in presence of additives ('enhancers') such as carbohydrates, polyethylene glycol, detergents, metal ions and through enzyme immobilization. In presence of iron, the E value for the kinetic resolution of (+/-)-3- and (+/-)-4-octyl sulfate was improved from E= 3.9 to greater than or equal to 200 and E= 1.1 to 10, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00363-4
• 作为产物：
  描述：

  3-辛醇 在 sodium hydride 、 三乙胺三氧化硫 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以87%的产率得到Natrium-n-Octylsulfat-(3)
  参考文献：
  名称：

  来自红球菌DSM 44541的烷基硫酸酯酶对仲烷基硫酸盐的对映选择性立体转化

  摘要：

  的对映选择性biohydrolysis秒-烷基硫酸酯使用来自细菌alkylsulfatase赤红球菌以立体选择性方式进行，虽然DSM 44541反转配置。因此，从外消旋底物中，将相应的（R）-对映异构体选择性地水解以提供相应的仲醇和未反应的硫酸酯，其均为（S）-构型，其代表均手性产物混合物。发现对映选择性取决于底物结构，并且最适合ω-1位的仲硫酸酯（最高E级）。= 21）。由于该酶对伯硫酸酯没有活性，因此可以分类为仲烷基硫酸酯酶[EC 3.1.6.X]。

  DOI：

  10.1016/s0957-4166(02)00362-2

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• [EN] IONIC LIQUIDS FOR DRUG DELIVERY<br/>[FR] LIQUIDES IONIQUES POUR L'ADMINISTRATION DE MÉDICAMENTS
  申请人：HARVARD COLLEGE

  公开号：WO2021102084A1

  公开（公告）日：2021-05-27

  The technology described herein is directed to ionic liquids and methods of drug delivery.

  本技术涉及离子液体及药物输送方法。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Phenolic resins
  申请人：BORDEN (UK) LIMITED

  公开号：EP0377996A1

  公开（公告）日：1990-07-18

  A cured phenolic resin may be prepared by reacting (1) an esterified phenolic compound containing one or more phenolic hydroxyl groups and/or one or more esterified phenolic hydroxyl groups and further containing one or more esterified methylol groups positioned ortho and/or para to a phenolic hydroxyl group or esterified phenolic hydroxyl group with (2) a phenolic novolak resin in the presence of a base and water or other polar solvent. The invention is particularly useful for the production of foundry moulds or cores wherein the above composition is used as a binder for a granular refractory material such as sand.

  固化酚醛树脂的制备方法是：(1)含有一个或多个酚羟基和/或一个或多个酯化酚羟基并进一步含有一个或多个与酚羟基或酯化酚羟基正交和/或对位的酯化甲醇基的酯化酚化合物与(2)酚醛新戊二烯树脂在碱和水或其他极性溶剂存在下反应。本发明特别适用于生产铸造模具或芯模，其中上述组合物用作砂等颗粒状耐火材料的粘结剂。
• Resin compositions having improved antistatic properties
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0422879A1

  公开（公告）日：1991-04-17

  Disclosed is a resin composition having excellent antistatic properties and practical physical properties. The resin comprises (i) a styrene resin; (ii) a polyethylene oxide having a viscosity-average molecular weight ranging from 15,000 to 1,200,000; (iii) either or both of a (meth) acrylate resin and an oxide selected from the group consisting of titanium oxide, zinc oxide and magnesium oxide; (iv) either a surfactant selected from specific sulfonic acid salts or a surfactant selected from specific alkyl sulfates; and, optionally, (v) a (poly)ethylene glycol having an average molecular weight ranging from 62 to 1,200. The resin composition also provides excellent resistance to hot water.

  本发明公开了一种具有优异抗静电性能和实用物理性能的树脂组合物。该树脂包括：(i) 苯乙烯树脂；(ii) 聚氧化乙烯，其粘度-平均分子量在 15,000 至 1,200,000 之间；(iii) (甲基) 丙烯酸酯树脂和选自氧化钛、氧化锌和氧化镁的氧化物中的一种或两种；(iv) 选自特定磺酸盐的表面活性剂或选自特定烷基硫酸盐的表面活性剂；以及 (v) 平均分子量在 62 到 1 200 之间的（聚）乙二醇。这种树脂组合物还具有优异的耐热水性。