2-(2-(4-(1,2-diphenylethyl)piperazin-1-yl)ethoxy)ethanol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-(2-(4-(1,2-diphenylethyl)piperazin-1-yl)ethoxy)ethanol
• 英文别名: 2-[2-[4-(1,2-Diphenylethyl)piperazin-1-yl]ethoxy]ethanol
• 化学式: C₂₂H₃₀N₂O₂
• 分子量: 354.492
• InChiKey: SSBAVQWBQISBDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  35.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-[2-(2-羟基乙氧基)乙基]哌嗪 、 bromozinc(1+),methanidylbenzene 、 苯甲醛 以 乙腈 为溶剂， 反应 4.0h， 以80%的产率得到2-(2-(4-(1,2-diphenylethyl)piperazin-1-yl)ethoxy)ethanol
  参考文献：
  名称：

  Straightforward three-component synthesis of diarylmethylpiperazines and 1,2-diarylethylpiperazines

  摘要：

  Several functionalized diarylmethylpiperazines and 1,2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or beta-arylethylpiperazines toward the use of paraformaldehyde or aliphatic aldehydes. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.02.086

文献信息

• Straightforward three-component synthesis of diarylmethylpiperazines and 1,2-diarylethylpiperazines
  作者：Stéphane Sengmany、Erwan Le Gall、Cédric Le Jean、Michel Troupel、Jean-Yves Nédélec

  DOI：10.1016/j.tet.2007.02.086

  日期：2007.4

  Several functionalized diarylmethylpiperazines and 1,2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or beta-arylethylpiperazines toward the use of paraformaldehyde or aliphatic aldehydes. (C) 2007 Elsevier Ltd. All rights reserved.