2,11-dichloro-13b-phenylbenzo[a]indeno[1,2-c]fluorene-9,14(8bH,13bH)-dione

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 芳基四氢萘木脂素
• 英文名称: 2,11-dichloro-13b-phenylbenzo[a]indeno[1,2-c]fluorene-9,14(8bH,13bH)-dione
• 英文别名: 6,21-Dichloro-2-phenylhexacyclo[15.7.0.02,10.03,8.011,16.018,23]tetracosa-1(17),3(8),4,6,11,13,15,18(23),19,21-decaene-9,24-dione；6,21-dichloro-2-phenylhexacyclo[15.7.0.02,10.03,8.011,16.018,23]tetracosa-1(17),3(8),4,6,11,13,15,18(23),19,21-decaene-9,24-dione
• 化学式: C₃₀H₁₆Cl₂O₂
• 分子量: 479.362
• InChiKey: JCAYZMGMGOZEJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  34
• 可旋转键数：
  1
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (2'-hydroxy-5'-chloroacetophenone)benzoylhydrazone 在 水 、 lead(IV) tetraacetate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 4.0h， 生成 2,11-dichloro-13b-phenylbenzo[a]indeno[1,2-c]fluorene-9,14(8bH,13bH)-dione
  参考文献：
  名称：

  Regioselective quadruple domino aldolization/aldol condensation/Michael/SNAr-cyclization: construction of hexacyclic indeno-fused C-nor-D-homo-steroid frameworks

  摘要：

  An operationally simple and highly atom-economic anionic quadruple domino reaction sequence for the synthesis of hexacyclic indeno-fused naphthalene/quinoline molecules having structural resemblance with the C-nor-D-homo-steroid nucleus has been developed. Promoter and solvent specificity, regioselectivity and mechanistic details were experimentally established. Catalyst concentration and solvent dependent switching of domino steps creating four new C-C bonds are discussed. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.01.059

文献信息

• Regioselective quadruple domino aldolization/aldol condensation/Michael/SNAr-cyclization: construction of hexacyclic indeno-fused C-nor-D-homo-steroid frameworks
  作者：Tanmoy Chanda、Sushobhan Chowdhury、B. Janaki Ramulu、Suvajit Koley、Raymond C.F. Jones、Maya Shankar Singh

  DOI：10.1016/j.tet.2014.01.059

  日期：2014.3

  An operationally simple and highly atom-economic anionic quadruple domino reaction sequence for the synthesis of hexacyclic indeno-fused naphthalene/quinoline molecules having structural resemblance with the C-nor-D-homo-steroid nucleus has been developed. Promoter and solvent specificity, regioselectivity and mechanistic details were experimentally established. Catalyst concentration and solvent dependent switching of domino steps creating four new C-C bonds are discussed. (C) 2014 Elsevier Ltd. All rights reserved.