cynsaccatol G

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cynsaccatol G
• 化学式: C₄₉H₆₅NO₁₅
• 分子量: 908.053
• InChiKey: XCSNDYMHSTVZPH-YGYVOTBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.77
• 重原子数：
  65.0
• 可旋转键数：
  11.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  225.32
• 氢给体数：
  5.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  cynsaccatol G 在 硫酸 、 水 作用下， 以 甲醇 为溶剂， 生成 β-D-digitoxopyranose 、 β-D-oleandrose
  参考文献：
  名称：

  C 21 steroidal glycosides from the roots of Cynanchum saccatum

  摘要：

  Eight new C-21 steroidal glycosides, named cynsaccatols A-H (1-8), along with two known analogs (9-10), were isolated from the roots of Cynanchum saccatum. Their structures were determined on the basis of detailed spectroscopic analysis, as well as HRESIMS. All compounds (1-10) were tested for their cytotoxicity in vitro using three human cancer cell lines (HepG2, Hela and U251), and compounds 1, 4, 5, 9, 10 showed weak inhibitory activities against different cell lines, respectively. (C) 2015 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.steroids.2015.05.009

文献信息

• C 21 steroidal glycosides from the roots of Cynanchum saccatum
  作者：Mi Zhang、Li-Li Rao、Cheng Xiang、Bao-Cai Li、Peng Li

  DOI：10.1016/j.steroids.2015.05.009

  日期：2015.9

  Eight new C-21 steroidal glycosides, named cynsaccatols A-H (1-8), along with two known analogs (9-10), were isolated from the roots of Cynanchum saccatum. Their structures were determined on the basis of detailed spectroscopic analysis, as well as HRESIMS. All compounds (1-10) were tested for their cytotoxicity in vitro using three human cancer cell lines (HepG2, Hela and U251), and compounds 1, 4, 5, 9, 10 showed weak inhibitory activities against different cell lines, respectively. (C) 2015 Elsevier Inc. All rights reserved.