2-(difluoromethyl)-2-methyl-2,3-dihydro-1H-perimidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(difluoromethyl)-2-methyl-2,3-dihydro-1H-perimidine
• 英文别名: 2-(Difluoromethyl)-2-methyl-1,3-dihydroperimidine；2-(difluoromethyl)-2-methyl-1,3-dihydroperimidine
• 化学式: C₁₃H₁₂F₂N₂
• 分子量: 234.248
• InChiKey: XKRDDNNLVWQDBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,1-二氟丙酮 、 1,8-二氨基萘 在 BF3 monohydrate complex 作用下， 反应 2.0h， 生成 2-(difluoromethyl)-2-methyl-2,3-dihydro-1H-perimidine
  参考文献：
  名称：

  Synthesis of perimidine and 1,5-benzodiazepine derivatives using tamed Brønsted acid, BF3–H2O

  摘要：

  The one pot synthesis of perimidine and 1,5-benzodiazepine derivatives via condensation of aryldiamines with ketones in the presence of BF3-H2O is described. BF3-H2O plays a dual role, as an efficient non-oxidizing Bronsted acid catalyst as well as an effective solvent making the reaction more economic and environmentally safer. The reaction is simple, fast and convenient. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2013.03.023

文献信息

• Synthesis of perimidine and 1,5-benzodiazepine derivatives using tamed Brønsted acid, BF3–H2O
  作者：G.K. Surya Prakash、Farzaneh Paknia、Arjun Narayan、Thomas Mathew、George A. Olah

  DOI：10.1016/j.jfluchem.2013.03.023

  日期：2013.8

  The one pot synthesis of perimidine and 1,5-benzodiazepine derivatives via condensation of aryldiamines with ketones in the presence of BF3-H2O is described. BF3-H2O plays a dual role, as an efficient non-oxidizing Bronsted acid catalyst as well as an effective solvent making the reaction more economic and environmentally safer. The reaction is simple, fast and convenient. (C) 2013 Elsevier B.V. All rights reserved.