3-(2-phenylsulfanyl-acetylamino)-benzo[b]thiophene-2-carboxylic acid methyl ester | 895485-07-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 3-(2-phenylsulfanyl-acetylamino)-benzo[b]thiophene-2-carboxylic acid methyl ester
• 英文别名: Methyl 3-(2-(phenylthio)acetamido)benzo[b]thiophene-2-carboxylate；methyl 3-[(2-phenylsulfanylacetyl)amino]-1-benzothiophene-2-carboxylate
• CAS: 895485-07-1
• 化学式: C₁₈H₁₅NO₃S₂
• 分子量: 357.454
• InChiKey: XLHBSDQITRKFBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES SUBSTITUTED WITH AMIDE, PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME<br/>[FR] DÉRIVÉS DE BENZOFURANE ET DE BENZOTHIOPHÈNE À SUBSTITUTION AMIDE, PROCÉDÉ DE PRÉPARATION DE CEUX-CI ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CEUX-CI
  申请人：KOREA RES INST CHEM TECH

  公开号：WO2009048274A2

  公开（公告）日：2009-04-16

  The present invention relates to a novel benzofuran or benzothiophene derivative substituted with amide. The inventive benzofuran or benzothiophene derivative substituted with amide effectively inhibits ischemic cell death, and thus, can be advantageously used for preventing and treating ischemic diseases such as brain ischemia, heart ischemia, diabetic cardiovascular disease, heart failure, myocardial hypertrophy, retinal ischemia, ischemic colitis, ischemic acute renal failure, stroke, head trauma, Alzheimer's disease, Parkinson's disease, neonatal hypoxia, glaucoma, and diabetic neuropathy.