2,7-diamino-4-(naphthalen-2-yl)-4H-chromene-3-carbonitrile | 331857-02-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,7-diamino-4-(naphthalen-2-yl)-4H-chromene-3-carbonitrile
• 英文别名: Sdccgsbi-0096745.P001；2,7-diamino-4-naphthalen-2-yl-4H-chromene-3-carbonitrile
• CAS: 331857-02-4
• 化学式: C₂₀H₁₅N₃O
• 分子量: 313.359
• InChiKey: JZJOSVNTFVUQIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.64
• 重原子数：
  24.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  85.06
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1-萘甲醛 、 3-氨基苯酚 、 丙二腈 在 potassium carbonate 作用下， 以76%的产率得到2,7-diamino-4-(naphthalen-2-yl)-4H-chromene-3-carbonitrile
  参考文献：
  名称：

  Highly efficient one-pot synthesis of dihydropyran heterocycles

  摘要：

  Diammonium hydrogen phosphate and potassium carbonate-catalyzed one-pot synthesis of 1,4-phenylene-bis(2-amino-4H-pyran-3-carbonitrile and 2-amino-4-aryl-4H-pyran-3-carbonitrile derivatives has been achieved by a three-component cyclocondensation of aldehydes, malononitrile, and different nucleophiles in aqueous medium in high yields. (C) 2013 Mohamed A. Ameen. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.11.041

文献信息

• Highly efficient one-pot synthesis of dihydropyran heterocycles
  作者：Mohamed A. Ameen、Sara M. Motamed、Fathy F. Abdel-latif

  DOI：10.1016/j.cclet.2013.11.041

  日期：2014.2

  Diammonium hydrogen phosphate and potassium carbonate-catalyzed one-pot synthesis of 1,4-phenylene-bis(2-amino-4H-pyran-3-carbonitrile and 2-amino-4-aryl-4H-pyran-3-carbonitrile derivatives has been achieved by a three-component cyclocondensation of aldehydes, malononitrile, and different nucleophiles in aqueous medium in high yields. (C) 2013 Mohamed A. Ameen. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.