7H-pyrazolo[4,3-b]pyridine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 7H-pyrazolo[4,3-b]pyridine-3-carboxylic acid
• 化学式: C₇H₅N₃O₂
• 分子量: 163.13
• InChiKey: TVKIKFFLELNRHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  74.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ALKYNYL ALCOHOLS AND METHODS OF USE
  申请人：Genentech, Inc.

  公开号：US20170145034A1

  公开（公告）日：2017-05-25

  The invention relates to compounds of Formula (0): wherein Q, A 1 -A 8 , R 4 and R 5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.