CDDO-TFEA

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: CDDO-TFEA
• 英文别名: (4aS,6aR,6bS,8aR,12aS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-N-(2,2,2-trifluoroethyl)-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxamide
• 化学式: C₃₃H₄₃F₃N₂O₃
• 分子量: 572.711
• InChiKey: UBRASLQCAYTTEB-GZNFCTEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  41
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  87
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (4aS,6aR,6bS,8aR,12aS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carbonyl chloride 、 2,2,2-三氟乙胺盐酸盐 在 碳酸氢钠 作用下， 以 水 、 苯酚 为溶剂， 生成 CDDO-TFEA
  参考文献：
  名称：

  WO2008/136838

  摘要：

  公开号：

文献信息

• Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
  申请人：REATA PHARMACEUTICALS, INC.

  公开号：US10556858B2

  公开（公告）日：2020-02-11

  This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

  本发明提供但不限于具有以下式子的新型齐墩果酸衍生物： 其中的变量在此定义。此外，还提供了包含这些化合物的药物组合物、试剂盒和制成品，以及用于制造这些化合物的方法和中间体，以及使用这些化合物和组合物的方法。
• Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof
  申请人：REATA PHARMACEUTICALS, INC.

  公开号：US10953020B2

  公开（公告）日：2021-03-23

  The present invention provides methods of treating or preventing Alport syndrome in a patients in need thereof using bardoxolone methyl or analogs thereof, and/or improving the kidney function of patients who have been diagnosed with Alport syndrome.

  本发明提供了使用甲基巴度唑酮或其类似物治疗或预防有需要的患者的阿尔波特综合征的方法，和/或改善已确诊为阿尔波特综合征患者的肾功能的方法。
• SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE
  申请人：Sporn Michael B.

  公开号：US20090326063A1

  公开（公告）日：2009-12-31

  The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
• METHODS OF TREATING OBESITY USING ANTIOXIDANT INFLAMMATION MODULATORS
  申请人：Meyer Colin J.

  公开号：US20110281955A1

  公开（公告）日：2011-11-17

  The present invention relates to methods of treating and/or preventing obesity comprising the administration of antioxidant inflammation modulators described herein, including for example bardoxolone methyl.
• Betulinic Acid Derivatives and Methods of Use Thereof
  申请人：Honda Tadashi

  公开号：US20120101149A1

  公开（公告）日：2012-04-26

  This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Treatment methods and methods of manufacture are also provided.