N-hexyl-N,N',N'-trimethyl-ethylenediamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-hexyl-N,N',N'-trimethyl-ethylenediamine
• 英文别名: N-Hexyl-N,N',N'-trimethyl-aethylendiamin；N'-hexyl-N,N,N'-trimethylethane-1,2-diamine
• 化学式: C₁₁H₂₆N₂
• 分子量: 186.341
• InChiKey: GYBRMJYKAZYESB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-己基甲胺 、 2-氯-N,N-二甲基乙胺 在 xylene 作用下， 生成 N-hexyl-N,N',N'-trimethyl-ethylenediamine
  参考文献：
  名称：

  Derivatives of Dimethylaminoethanol and Dimethylaminoethylamine

  摘要：

  DOI：

  10.1021/ja01125a050

文献信息

• Compositions comprising thermoplastic acrylate-crosslinked vinyl aromatic interpolymer elastomers and polyamides
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0322560A2

  公开（公告）日：1989-07-05

  Thermoplastic compositions comprising (i) a thermoplastic elastomer comprising a crosslinked (meth)acrylate phase and a crosslinked interpenetrating phase comprising a polymerized vinyl aromatic, alone, or in further combination with a polymerized acrylonitrile and (ii) polyamide resins because of their polyamide content have improved solvent resistance, wear resistance and high temperature capabilities. If the polyamide is an amorphous polyamide, the compositions have improved barrier properties. The thermoplastic elastomer component contributes improved impact resistance, weatherability, improved processability and lower water absorption.

  热塑性组合物包括：(i) 由交联（甲基）丙烯酸酯相和交联互穿相组成的热塑性弹性体，交联互穿相由聚合乙烯基芳香族（单独或与聚合丙烯腈进一步结合）和(ii) 聚酰胺树脂组成，由于含有聚酰胺，因此具有更好的耐溶剂性、耐磨性和耐高温性能。如果聚酰胺是无定形聚酰胺，则组合物的阻隔性能会得到改善。热塑性弹性体成分可提高抗冲击性、耐候性、加工性和吸水性。
• Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
  申请人：Arvinas, Inc.

  公开号：US10723717B2

  公开（公告）日：2020-07-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，它们可用作快速加速纤维肉瘤（RAF，如c-RAF、A-RAF和/或B-RAF；靶蛋白）的调节剂。特别是，本公开内容涉及双功能化合物，其一端含有与相应 E3 泛素连接酶结合的 Von Hippel-Lindau、cereblon、抑制细胞凋亡蛋白或小鼠双敏同源物 2 配体，另一端含有与靶蛋白 RAF 结合的分子，从而将靶蛋白置于泛素连接酶附近，以实现对靶蛋白的降解（和抑制）。本公开物具有与降解/抑制靶蛋白相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防由于靶蛋白的聚集或积聚或靶蛋白的组成性激活而导致的疾病或失调。
• Derivatives of Dimethylaminoethanol and Dimethylaminoethylamine
  作者：Godfrey F. Grail、Leon E. Tenenbaum、Alexander V. Tolstoouhov、Charles J. Duca、John F. Reinhard、Floyd E. Anderson、John V. Scudi

  DOI：10.1021/ja01125a050

  日期：1952.3