(5-Phenylisoquinolin-8-yl)methanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (5-Phenylisoquinolin-8-yl)methanamine
• 化学式: C₁₆H₁₄N₂
• 分子量: 234.29
• InChiKey: CDKNJMFDOSPZFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
  申请人：Merck Sharp & Dohme Corp.

  公开号：US10568876B2

  公开（公告）日：2020-02-25

  The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.

  本发明涉及由式（I）代表的化合物及其药学上可接受的盐类。式（I）化合物是二酰基甘油 O-酰基转移酶 2（"DGAT2"）的抑制剂，可用于治疗、预防和抑制由 DGAT2 介导的疾病。本发明的化合物可用于治疗肝脂肪变性、糖尿病、肥胖症、高脂血症、高胆固醇血症、动脉粥样硬化、心肾疾病（如慢性肾脏疾病和心力衰竭）以及相关疾病和病症。
• ISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP3188731B1

  公开（公告）日：2019-04-03
• TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20170273965A1

  公开（公告）日：2017-09-28

  The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
• US9828369B2
  申请人：——

  公开号：US9828369B2

  公开（公告）日：2017-11-28
• US9877957B2
  申请人：——

  公开号：US9877957B2

  公开（公告）日：2018-01-30