四乙基1,2-二苯基乙烷-1,1,2,2-四羧酸酯 | 117720-83-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 四乙基1,2-二苯基乙烷-1,1,2,2-四羧酸酯
• 英文名称: tetraethyl 1,2-diphenyl-1,1,2,2-ethanetetracarboxylate
• 英文别名: tetraethyl 1,2-diphenylethane-1,1,2,2-tetracarboxylate；1,1,2,2-tetracarbethoxy-1,2-diphenylethane；1,1,2,2-Tetraethyl 1,2-diphenyl-1,1,2,2-ethanetetracarboxylate
• CAS: 117720-83-9
• 化学式: C₂₆H₃₀O₈
• 分子量: 470.519
• InChiKey: JAFOKVDVUVUQBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  34
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  苯基丙二酸二乙酯 在 sodium ethanolate 作用下， 以 乙腈 为溶剂， 以50%的产率得到四乙基1,2-二苯基乙烷-1,1,2,2-四羧酸酯
  参考文献：
  名称：

  Peek, Reinhold; Streukens, Marlies; Thomas, Hans Guenter, Chemische Berichte, 1994, vol. 127, # 7, p. 1257 - 1262

  摘要：

  DOI：

文献信息

• Oxidative dimerization of diethyl 3-thienylmalonate by high valent metal salts. Synthesis of benzo[1,2-b:4,5-b′]dithiophene derivatives
  作者：Attilio Citterio、Roberto Sebastiano、Antonietta Maronati、Fabio Viola、Alessandra Farina

  DOI：10.1016/0040-4020(96)00797-1

  日期：1996.10

  The oxidation of diethyl 3-thienylmalonate (1) by metal oxidants (Fe(ClO4)3, Mn(OAc)3, MnO2 and CuO) in various solvents at 60 °C affords dimerization products arising from side-chain and nuclear coupling of the intermediate delocalized malonyl radicals 6. Metal to sulphur binding is suggested to play a role in controlling the distribution of dimers 2 – 5. The higher thermodynamic stability of unsymmetric

  2-噻吩丙二酸二乙酯（1）在60°C下于各种溶剂中被金属氧化剂（Fe（ClO 4）3，Mn（OAc）3，MnO 2和CuO）氧化产生的二聚化产物是由侧链和核偶联产生中间离域丙二酸基6。建议金属与硫的结合在控制二聚体2 – 5的分布中发挥作用。不对称二聚体3的较高热力学稳定性，以及其氧化性的分子内1,6-环化为4，使得可以开发新的简单合成苯并[1,2-b：4,5-b']二噻吩衍生物15-18。
• Citterio, Attilio; Finzi, Claudia; Santi, Roberto, Journal of Chemical Research, Miniprint, 1988, # 5, p. 1301 - 1331
  作者：Citterio, Attilio、Finzi, Claudia、Santi, Roberto、Strologo, Sauro

  DOI：——

  日期：——
• Manganese(III)-mediated carbon-carbon bond formation in the reaction of xanthenes with active methylene compounds
  作者：Hiroshi Nishino、Hironori Kamachi、Harumi Baba、Kazu Kurosawa

  DOI：10.1021/jo00039a010

  日期：1992.6

  Oxidation of xanthenes with manganese(III) acetate in the presence of active methylene compounds such as 1,3-dicarbonyl compounds, malononitrile derivatives, acetone, and nitromethane selectively gives 9-substituted xanthene derivatives in good yields. A similar oxidation of thioxanthene also yields 2-(9-thioxanthenyl)-1,3-dicarbonyl compounds in 57-91% yields. The obtained 2-(9-xanthenyl)-1,3-dicarbonyl compounds are readily converted to 2-(9-xanthenylidene)-1,3-dicarbonyl derivatives using manganese(III) complexes or 2,3-dichloro-5, 6-dicyano-1,4-benzoquinone. The mechanisms for the formation of 9-substituted xanthenes are discussed on the basis of the reaction of intermediates, the electron-donating substituent effect on the xanthene ring system, effect of additives, and comparison with a reaction of radical-trapping reagents.
• Electron transfer process. 49. Radical and ionic reactions of (benzoylmethyl)mercurials
  作者：Glen A. Russell、Shekhar V. Kulkarni、Rajive K. Khanna

  DOI：10.1021/jo00290a050

  日期：1990.2
• Oxidation of malonic acid derivatives by manganese(III) acetate. Aromatic malonylation reaction. Scope and limitations
  作者：Attilio Citterio、Roberto Santi、Tiziana Fiorani、Sauro Strologo

  DOI：10.1021/jo00272a046

  日期：1989.5