16-heptadecenyl-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 16-heptadecenyl-1-amine
• 英文别名: Heptadec-16-en-1-amine
• 化学式: C₁₇H₃₅N
• 分子量: 253.472
• InChiKey: ZOQFUVJHZVBEMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  18
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  三苯基甲基溴 、 16-heptadecenyl-1-amine 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以96%的产率得到16-heptadecenyl-1-(N-triphenylmethyl)amine
  参考文献：
  名称：

  Synthesis of Model Compounds for the Formation of Self-Assembled Monolayers on a Silicon Surface

  摘要：

  据报道，末端官能化烷烃的合成是形成自组装单分子层的潜在化合物。所述烷烃的一端被适合连接至羟基化硅表面的三氯或三烷氧基甲硅烷基取代，而另一方面被乙烯基或氨基取代以进一步官能化。

  DOI：

  10.1055/s-1995-4058
• 作为产物：
  描述：

  16-heptadecenyl-1-amine hydrochloride 在 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以98%的产率得到16-heptadecenyl-1-amine
  参考文献：
  名称：

  Synthesis of Model Compounds for the Formation of Self-Assembled Monolayers on a Silicon Surface

  摘要：

  据报道，末端官能化烷烃的合成是形成自组装单分子层的潜在化合物。所述烷烃的一端被适合连接至羟基化硅表面的三氯或三烷氧基甲硅烷基取代，而另一方面被乙烯基或氨基取代以进一步官能化。

  DOI：

  10.1055/s-1995-4058

文献信息

• AMINOALCOHOL LIPIDOIDS AND USES THEREOF
  申请人：Massachusetts Institute Of Technology

  公开号：EP3269395A1

  公开（公告）日：2018-01-17

  Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文介绍了通过胺与环氧化物封端化合物反应制备氨基醇脂质的方法。还提供了从市售起始原料制备氨基醇类脂质的方法。氨基醇脂质可由外消旋或立体化学纯环氧化物制备。氨基醇类脂质或其盐类最好具有生物降解性和生物相容性，可用于各种给药系统。考虑到这些氨基醇类脂化合物的氨基，它们特别适合用于多核苷酸的给药。现已制备出含有本发明类脂化合物和多核苷酸的复合物、胶束、脂质体或颗粒。本发明的类脂质还可用于制备给药微粒。由于本发明脂质具有缓冲周围环境 pH 值的能力，因此在递送易变药剂方面特别有用。
• KAUFMAN, B. J.;LEVIN, M. D
  作者：KAUFMAN, B. J.、LEVIN, M. D

  DOI：——

  日期：——
• QUINAZOLINONE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS
  申请人：Astex Therapeutics Limited

  公开号：EP2989092B1

  公开（公告）日：2017-08-30
• PROCESS FOR PRODUCING ALKYLENE OXIDE ADDUCT AND ALKYLENE OXIDE ADDUCT
  申请人：TAKEMOTO YUSHI KABUSHIKI KAISHA

  公开号：US20160368847A1

  公开（公告）日：2016-12-22

  This is to provide a process for producing an alkylene oxide adduct which can continuously produce the alkylene oxide adduct with an optional size from a small size to a large size, a temperature and a pressure at the time of the addition reaction can be controlled with high precision, and as a result, the alkylene oxide adduct with high quality having no coloring and narrow molecular weight distribution can be continuously produced, and the above can be accomplished simultaneously, and such an alkylene oxide adduct. An alkylene oxide adduct was produced by using a microflow reactor having a flow passage with an inner diameter of 0.05 to 3.5 mm, continuously supplying a predetermined amount of alkylene oxide and a predetermined amount of an organic compound having an active hydrogen atom(s) to the flow passage in a liquid state, and these materials were reacted while passing therethrough under the conditions of a temperature of the flow passage of 70 to 200° C. and a pressure of the supply port of the flow passage of 1 to 10 MPa.
• Synthesis of Model Compounds for the Formation of Self-Assembled Monolayers on a Silicon Surface
  作者：Franz Effenberger、Stephan Heid

  DOI：10.1055/s-1995-4058

  日期：1995.9

  The synthesis of terminally functionalized alkanes, which represent potential compounds for formation of self-assembled monolayers, is reported. The alkanes described are substituted at one end with a trichloro- or trialkoxysilyl group suitable for linkage to a hydroxylated silicon surface and at the other hand with a vinyl or amino group for further functionalization.

  据报道，末端官能化烷烃的合成是形成自组装单分子层的潜在化合物。所述烷烃的一端被适合连接至羟基化硅表面的三氯或三烷氧基甲硅烷基取代，而另一方面被乙烯基或氨基取代以进一步官能化。