1,2-dibromo-4-methyl-cyclohexanecarboxylic acid

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 1,2-dibromo-4-methyl-cyclohexanecarboxylic acid
• 英文别名: 1,2-Dibrom-4-methyl-cyclohexancarbonsaeure；1,2-dibromo-4-methylcyclohexanecarboxylic acid；1,2-Dibromo-4-methylcyclohexane-1-carboxylic acid
• 化学式: C₈H₁₂Br₂O₂
• 分子量: 299.99
• InChiKey: DLORUQGTKNPHNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲基环己烯-1-羧酸 在 溴 作用下， 生成 1,2-dibromo-4-methyl-cyclohexanecarboxylic acid
  参考文献：
  名称：

  Perkin; Pickles, Journal of the Chemical Society, 1905, vol. 87, p. 657

  摘要：

  DOI：

文献信息

• Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
  申请人：University of Illinois Foundation

  公开号：EP0048149A1

  公开（公告）日：1982-03-24

  Novel antibiotics named didenmins A, B and C and nordidemnins A, B and C have been obtained from a marine organism named Trididemnum sp. These antibiotics are active against a variety of DNA and RNA viruses.

  从一种名为 Trididemnum sp.的海洋生物中获得了名为 didenmins A、B 和 C 以及 nordidemnins A、B 和 C 的新型抗生素。
• Glycosides isolated from the Euphorbiaceae genus Phyllanthus and their anti-tumour use
  申请人：UNIVERSITY PATENTS, INC.

  公开号：EP0087861A1

  公开（公告）日：1983-09-07

  New antineoplastic glycosides, phyllanthostatin 1,2 and 3, of formula: and the related glycoside, phyllanthoside, have been isolated from the Central American tree, Phyllanthus acuminatus Vahl. These compounds exhibit activity against the National Cancer Institute's P388 lymphocytic leukemia. Also, phyllanthoside was found to possess a curative level of activity against the murine B16 malanoma.

  从中美洲树种 Phyllanthus acuminatus Vahl 中分离出了新的抗肿瘤苷--式：的 phyllanthostatin 1、2 和 3，以及相关的苷--phyllanthoside。 这些化合物对美国国家癌症研究所的 P388 淋巴细胞白血病具有活性。 此外，还发现 phyllanthoside 对小鼠 B16 恶性肿瘤具有治疗活性。
• Bryozoan antibiotics
  申请人：ARIZONA BOARD OF REGENTS

  公开号：EP0109811A2

  公开（公告）日：1984-05-30

  Potent antineoplastic agents designated bryostatin 1, bryostatin 2 and bryostatin 3 have been isolated from the marine animal Bugula neritina L. (Bryozoan phylum).

  从海洋动物 Bugula neritina L.（毛环节动物门）中分离出了强效抗肿瘤药物，分别命名为白僵菌素 1、白僵菌素 2 和白僵菌素 3。
• Antibiotics
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：EP0133000A2

  公开（公告）日：1985-02-13

  New antibiotics, which have been named Eudistomins, have been obtained from marine organisms. These compounds, which can have anti-viral, as well as anti-bacteria and anti-tumour activity in some cases, are, chemically, derivatives of 5H-pyrido[3,4-b]indole.

  从海洋生物中获得了被命名为 Eudistomins 的新型抗生素。这些化合物在某些情况下具有抗病毒、抗菌和抗肿瘤活性，在化学上是 5H-吡啶并[3,4-b]吲哚的衍生物。
• Bryostatins
  申请人：ARIZONA BOARD OF REGENTS

  公开号：EP0264173A2

  公开（公告）日：1988-04-20

  New and exceptionally potent antineoplastic agents denominated Bryostatin 9, Bryostatin 10, Bryostatin 11, Bryostatin 12 and Bryostatin 13 have been isolated from the marine animal Bugula neritina (Linneaeus) (Bryozoan phylum) and the structures identified. Meaningful antineoplastic activity is found for each.

  从海洋动物 Bugula neritina（Linneaeus）（毛霉菌门）中分离出了新型特效抗肿瘤物质，分别称为 Bryostatin 9、Bryostatin 10、Bryostatin 11、Bryostatin 12 和 Bryostatin 13，并确定了其结构。每种物质都具有重要的抗肿瘤活性。