1-(1-naphthylacetyl)-4-(p-ethoxyphenyl)thiosemicarbazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(1-naphthylacetyl)-4-(p-ethoxyphenyl)thiosemicarbazide
• 英文别名: 1-(1-naphthoacetyl)-4-p-ethoxyphenyl thiosemicarbazide；1-(4-Ethoxyphenyl)-3-[(2-naphthalen-1-ylacetyl)amino]thiourea
• 化学式: C₂₁H₂₁N₃O₂S
• 分子量: 379.483
• InChiKey: MKEHSRRVDOROCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  94.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-萘乙酰肼 、 4-乙氧基苯基硫氰酸酯 反应 0.3h， 以90.3%的产率得到1-(1-naphthylacetyl)-4-(p-ethoxyphenyl)thiosemicarbazide
  参考文献：
  名称：

  AN EFFICIENT SOLID-STATE METHOD FOR THE PREPARATION OF ACYL THIOSEMICARBAZIDES

  摘要：

  Solid-state syntheses of acyl thiosemicarbazides are reported for the first time. Eleven acyl thiosemicarbazides have been synthesized at room temperature in excellent yields (84.5 similar to 91.0%). Among them, eight compounds 3a, 3d, 3e, 3g-k are new. The reaction proves to be extremely simple and highly efficient (in 6 similar to 18 min).

  DOI：

  10.1081/scc-100104325

文献信息

• AN EFFICIENT SOLID-STATE METHOD FOR THE PREPARATION OF ACYL THIOSEMICARBAZIDES
  作者：Jian-Ping Li、Qian-Fu Luo、Yu-Lu Wang、Hong Wang

  DOI：10.1081/scc-100104325

  日期：2001.1

  Solid-state syntheses of acyl thiosemicarbazides are reported for the first time. Eleven acyl thiosemicarbazides have been synthesized at room temperature in excellent yields (84.5 similar to 91.0%). Among them, eight compounds 3a, 3d, 3e, 3g-k are new. The reaction proves to be extremely simple and highly efficient (in 6 similar to 18 min).
• Li, Jian-Ping; Luo, Qian-Fu; Wang, Yu-Lu, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002, vol. 41, # 9, p. 1962 - 1963
  作者：Li, Jian-Ping、Luo, Qian-Fu、Wang, Yu-Lu

  DOI：——

  日期：——