3-Aminostilbene

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3-Aminostilbene
• 英文别名: 3-styrylaniline；3Aminostilbene；3-(2-phenylethenyl)aniline
• 化学式: C₁₄H₁₃N
• 分子量: 195.264
• InChiKey: STNDIHAVRCIBCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-Aminostilbene 在 碘 作用下， 以 乙醚 、 正己烷 为溶剂， 生成 2-菲基胺
  参考文献：
  名称：

  Luminescence of N-Arylbenzamides in Low-Temperature Glasses

  摘要：

  The low-temperature luminescence of benzamide and six additional N-arylbenzamides has been investigated in a methyltetrahydrofuran glass. The luminescence of microcrystalline benzamide has also been studied. Assignments of the fluorescence and phosphorescence have been made on the basis of comparisons with the spectra of benzamide and the six aminoarenes and with the results of semiempirical ZINDO calculations for the amines and amides. This information was used to construct state-energy diagrams for the six amides. The 430 nm fluorescence of benzanilide and the amides derived from 4-aminobiphenyl and 4-aminodiphenyl-acetylene is assigned to a n,pi* state having a relaxed geometry and localized on the benzoyl group. The structured fluorescence of the amides derived from 4-aminostilbene and 2-aminoanthracene is attributed to a delocalized pi,pi* singlet slate, The amide derived from 2-aminophenanthrene displays dual fluorescence. The amides derived from 4-aminostilbene and 2-aminoanthracene are nonphosphorescent. The structured phosphorescence of the amides derived from the other aminoarenes is assigned to a pi,pi* triplet state similar to that for the aminoarene. These results serve to further elucidate the unusual luminescence properties of the benzamides in solution as well as in low-temperature glasses.

  DOI：

  10.1021/jp9927294
• 作为产物：
  描述：

  3-硝基苯乙酸 在 哌啶 、 sodium sulfide 、 水 作用下， 生成 3-Aminostilbene
  参考文献：
  名称：

  纯空间位阻对分子内质子在激发态下的质子转移的影响以及在近红外激光辐照下共轭新染料的光物理性质

  摘要：

  这项研究提出了多种带有内部质子转移链段的新型扩展共轭染料，它们具有不同程度的空间位阻。此外，合成了缺乏质子转移部分的染料作为参考。1个1 H NMR谱和X射线单晶显示目标染料中存在内部氢键。研究表明，空间位阻较小或中等的目标染料在激发态下均表现出内部质子转移，因此在单光子和近红外双光子辐照下分别产生双发射带，而空间位阻较重的染料显示出在激发态下分子内质子转移发射相当弱，甚至没有。进一步进行了分子建模以了解空间位阻对目标染料在激发态下内部质子转移的抑制作用。

  DOI：

  10.1016/j.dyepig.2017.06.064

文献信息

• Multifunctional cyclodextrin-based N,N-bidentate ligands for aqueous Heck arylation
  作者：Jonathan Potier、Stéphane Menuel、Jolanta Rousseau、Sigitas Tumkevicius、Frédéric Hapiot、Eric Monflier

  DOI：10.1016/j.apcata.2014.04.021

  日期：2014.6

  Novel Pd(II) complexes coordinated by N,N-bidentate ligands derived from cyclodextrins have been synthesized by copper-catalyzed azide alkyne 1,3-cycloaddition (CuAAC). Depending on the nature of the N,N-bidentate ligand, fast or slow equilibriums between the free N,N-bidentate ligand and the Pd-species were detected by NMR measurements. The new Pd(II) complexes acted as efficient water soluble catalysts

  通过铜催化的叠氮化物炔烃1,3-环加成反应（CuAAC）合成了由环糊精衍生的N，N-二齿配体配位的新型Pd（II）配合物。取决于N，N-双齿配体的性质，通过NMR测量来检测游离的N，N-双齿配体和Pd-物种之间的快速或缓慢平衡。新的Pd（II）配合物可作为水性介质中芳基碘化物的Heck反应的高效水溶性催化剂。该反应可以耐受有氧条件，并以良好的产率提供偶联产物。一旦反应完成，可以通过简单的倾析将产物和催化剂分别回收。
• [EN] HETEROCYCLIC DERIVATIVES AND USE THEREOF<br/>[FR] DÉRIVÉS HÉTÉROCYCLIQUES ET LEUR UTILISATION
  申请人：C & C RES LAB

  公开号：WO2014196793A1

  公开（公告）日：2014-12-11

  A heterocyclic derivative represented by formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, which has an inhibitory effect on the activation of STAT3 protein, and is useful for the prevention or treatment of diseases associated with the activation of STAT3 protein.

  由式(I)表示的杂环衍生物，或其药用可接受的盐或立体异构体，对STAT3蛋白激活具有抑制作用，并可用于预防或治疗与STAT3蛋白激活相关的疾病。
• Anti-influenza activity of phenethylphenylphthalimide analogs derived from thalidomide
  作者：Yuma Iwai、Hitoshi Takahashi、Dai Hatakeyama、Kazunori Motoshima、Minoru Ishikawa、Kazuyuki Sugita、Yuichi Hashimoto、Yuichi Harada、Shigeyuki Itamura、Takato Odagiri、Masato Tashiro、Yoshihisa Sei、Kentaro Yamaguchi、Takashi Kuzuhara

  DOI：10.1016/j.bmc.2010.05.035

  日期：2010.7

  subunits. We identified potential novel anti-influenza agents from a screen of 34 synthesized phenethylphenylphthalimide analogs derived from thalidomide (PPT analogs). For this screen we used a PA endonuclease inhibition assay, a PB2 pathogenicity-determinant domain-binding assay, and an anti-influenza A virus assay. Three PPT analogs, PPT-65, PPT-66, and PPT-67, were found to both inhibit PA endonuclease

  源自猪的甲型流感病毒已在​​全世界引起大流行，甲型流感被认为是严重的全球健康问题。因此，非常需要靶向这些病毒的新型药物。甲型流感病毒表达对其转录和复制必不可少的RNA聚合酶，该酶包含PA，PB1和PB2亚基。我们从34种合成的来自沙利度胺的苯乙基苯基邻苯二甲酰亚胺类似物（PPT类似物）的筛选中鉴定出潜在的新型抗流感药。对于此筛选，我们使用了PA核酸内切酶抑制测定，PB2致病性决定域结合测定和抗A型流感病毒测定。发现三种PPT类似物PPT-65，PPT-66和PPT-67均能抑制PA核酸内切酶活性并延缓甲型流感的生长，表明它们的活性之间存在相关性。还发现PPT-28抑制甲型流感的生长。这四个类似物共有3,4-二羟基苯乙基。我们还讨论了3,4-二羟基苯乙基柔韧性可能在PA核酸内切酶抑制中起重要功能作用的可能性。另一个带有二甲氧基苯乙基的类似物PPT-62具有PB2致病性决定域结合活性，但没有抑
• Hydrogenation of nitroarenes using defined iron–phosphine catalysts
  作者：Gerrit Wienhöfer、Mario Baseda-Krüger、Carolin Ziebart、Felix A. Westerhaus、Wolfgang Baumann、Ralf Jackstell、Kathrin Junge、Matthias Beller

  DOI：10.1039/c3cc42983k

  日期：——

  A novel iron-catalyzed hydrogenation of nitroarenes to the corresponding amines is reported. An in situ combination of Fe(BF4)2·6H2O and phosphine allows for highly selective hydrogenation of a broad range of aromatic and nitroarenes tolerating different functional groups.

  报道了一种新型的铁催化氢化硝基芳烃制备相应胺的方法。通过Fe(BF4)2·6H2O和膦的现场组合，实现了对广泛的芳香和硝基芳烃的高选择性氢化，同时容忍不同的官能团。
• Synthesis and characterization of para-pyridine linked NHC palladium complexes and their studies for the Heck–Mizoroki coupling reaction
  作者：Ya-Ming Liu、Yi-Chun Lin、Wen-Ching Chen、Jen-Hao Cheng、Yi-Lin Chen、Glenn P. A. Yap、Shih-Sheng Sun、Tiow-Gan Ong

  DOI：10.1039/c2dt30520h

  日期：——

  This paper describes the synthesis of 1-(pyridine-4-ylmethyl) NHC and their Pd(II) and Ag(I) complexes, which are fully characterized. Interestingly, we have also synthesized a Pd complex 3a-CO33 using a more direct treatment of K2CO3 with PdCl2. 3a-CO33 represents the first reported solid structure of a Pd η2-carbonato complex stabilized by an NHC framework. 3a-CO33 can be easily converted to a PdCl2 derivative by treating it with chloroform. We have found these palladium complexes mediate the Heck–Mizoroki coupling with a low catalyst loading. Furthermore, we also expand such catalytic manifold toward constructing fused polyaromatic substrates, a highly useful class of compounds in optoelectronic chemistry.

  本文描述了1-(吡啶-4-基甲基) NHC的合成及其Pd(II)和Ag(I)配合物，这些配合物均已完全表征。有趣的是，我们还通过对K2CO3与PdCl2的更直接处理合成了Pd配合物3a-CO33。3a-CO33代表了首个报道的由NHC框架稳定的Pdη2-碳酸盐配合物的固体结构。3a-CO33可以通过与氯仿反应轻易转化为PdCl2衍生物。我们发现这些钯配合物可以以较低的催化剂负载量催化Heck–Mizoroki耦合反应。此外，我们还将这种催化体系扩展到构建融合的多芳香基底，这是在光电化学中一种非常有用的化合物类别。