tert-butyl ((2-oxo-4-(pyrrolidin-1-yl)-2,5-dihydrofuran-3-yl)methyl)carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: tert-butyl ((2-oxo-4-(pyrrolidin-1-yl)-2,5-dihydrofuran-3-yl)methyl)carbamate
• 英文别名: tert-butyl N-[(5-oxo-3-pyrrolidin-1-yl-2H-furan-4-yl)methyl]carbamate
• 化学式: C₁₄H₂₂N₂O₄
• 分子量: 282.34
• InChiKey: JKRIOQMNVQNXAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 氨基甲酸叔丁酯 、 4-(pyrrolidin-1-yl)-5H-furan-2-one 在 lithium perchlorate 作用下， 以 二氯甲烷 为溶剂， 以74%的产率得到tert-butyl ((2-oxo-4-(pyrrolidin-1-yl)-2,5-dihydrofuran-3-yl)methyl)carbamate
  参考文献：
  名称：

  Regioselective C5-alkylation and C5-methylcarbamate formation of 2,3-dihydro-4-pyridones and C3-alkylation and C3-methylcarbamate formation of 4-(pyrrolidin-1-yl)furan-2(5H)-one

  摘要：

  Reactions of N-alkyl-2,3-dihydro-4-pyridones and 4-(pyrrolidin-1-yl)furan-2(5H)-one with aldehydes and triethylsilane in a one-flask procedure provided C5 and C3 alkylated derivatives, respectively. Mannich-type reactions with formaldehyde and carbamates in the presence of lithium perchlorate furnished C5/C3 methylcarbamates. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.

  DOI：

  10.1016/j.tetlet.2015.09.004

文献信息

• Regioselective C5-alkylation and C5-methylcarbamate formation of 2,3-dihydro-4-pyridones and C3-alkylation and C3-methylcarbamate formation of 4-(pyrrolidin-1-yl)furan-2(5H)-one
  作者：Xingxian Gu、Gunda I. Georg

  DOI：10.1016/j.tetlet.2015.09.004

  日期：2015.10

  Reactions of N-alkyl-2,3-dihydro-4-pyridones and 4-(pyrrolidin-1-yl)furan-2(5H)-one with aldehydes and triethylsilane in a one-flask procedure provided C5 and C3 alkylated derivatives, respectively. Mannich-type reactions with formaldehyde and carbamates in the presence of lithium perchlorate furnished C5/C3 methylcarbamates. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.