四溴十二烷基铵 | 14866-34-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 四溴十二烷基铵
• 中文别名: 四月桂基溴化铵；四(十二烷)基溴化铵
• 英文名称: tetra-n-dodecylammonium bromide
• 英文别名: Tetradecyltrimethylammonium bromide；tetradodecylmethylammonium bromide；tetra-Dodecylammonium bromide；tetradodecylammonium bromide；TDAB；tetradodecylazanium;bromide
• CAS: 14866-34-3
• 化学式: Br*C₄₈H₁₀₀N
• 分子量: 771.233
• InChiKey: SMEFTBPJZGVAPK-UHFFFAOYSA-M

物化性质

• 熔点：
  87-90 °C
• 碰撞截面：
  316.9 Ų [M*]+

计算性质

• 辛醇/水分配系数(LogP)：
  14.49
• 重原子数：
  50
• 可旋转键数：
  44
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26
• 危险类别码：
  R36/37/38
• 海关编码：
  2923900090
• WGK Germany：
  3
• 危险标志：
  GHS07
• 危险性描述：
  H315,H319,H335
• 危险性防范说明：
  P261,P305 + P351 + P338

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : Tetradodecylammonium bromide
CAS-No. : 14866-34-3

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Skin irritation (Category 2)
Eye irritation (Category 2)
Specific target organ toxicity - single exposure (Category 3)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Irritating to eyes, respiratory system and skin.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Warning
Hazard statement(s)
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary statement(s)
Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R36/37/38 Irritating to eyes, respiratory system and skin.
S-phrase(s)
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S36 Wear suitable protective clothing.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : C48H100BrN
Molecular Weight : 771,22 g/mol
Component Concentration
Tetradodecylammonium bromide
CAS-No. 14866-34-3 -
EC-No. 238-937-4

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Hydrogen bromide gas
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Immersion protection
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: > 480 min
Splash protection
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: > 30 min
test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
contact the supplier of the CE approved gloves. This recommendation is advisory only and must
be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our
customers. It should not be construed as offering an approval for any specific use scenario.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: crystalline
Colour: white
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing Melting point/range: 87 - 90 °C
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes serious eye irritation.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  四溴十二烷基铵 在 silver fluoride 作用下， 以 甲醇 为溶剂， 以78.7 %的产率得到Tetradodecylazanium;fluoride
  参考文献：
  名称：

  一种无水四正烷基氟化铵的制备方法

  摘要：

  本发明公开了一种无水四正烷基氟化铵的制备方法，通过使用无水甲醇或无水乙醇作为溶剂，为得到无水四正烷基氟化铵提供了有利条件；在10～30℃下进行离子交换，反应条件温和、离子交换程度较高；操作简便，不需要使用氢氟酸，对设备无特殊要求；适用于不同碳链的四正烷基氟化铵的合成；本发明提供的方法制备得到的四正烷基氟化铵的纯度大于99％，含水量低于0.1％，产品品质高。

  公开号：

  CN117567291A
• 作为试剂：
  描述：

  溴乙烷 、 2,4,5-三苯基咪唑 在 四溴十二烷基铵 、 potassium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 5.0h， 以92%的产率得到1-ethyl-2,4,5-triphenylimidazole
  参考文献：
  名称：

  Synthesis and Structure of 1-Ethyl-2,4,5-triphenyl-1H-imidazole (Ethyl-Lophine)

  摘要：

  采用改进的微波辅助方法合成了乙基-洛芬、1-乙基-2,4,5-三苯基-1H-咪唑（C23H20N2），作为离子液体中大型有机阳离子的前体。通过核磁共振、红外和 DSC 热测量以及元素分析，对标题化合物和一种前体化合物进行了表征。通过单晶 X 射线结构分析，确定了乙基-洛芬的晶体结构（三菱形，P1̄，a = 10:1137(3)，b = 12:4935(4)，c = 14:6351(4) Å，α = 98:182(2)°，β = 90:694(2)°，γ = 102:666(2)°，Z = 4，wR2 = 0:1030，共 611 个细化参数）。

  DOI：

  10.5560/znb.2013-2333

文献信息

• Synthesis, Properties, and Structures of Salts with the Reineckate Anion, [CrIII(NCS)4(NH3)2]-, and Large Organic Cations
  作者：Tim Peppel、Christin Schmidt、Martin Köckerling

  DOI：10.1002/zaac.201100091

  日期：2011.8

  measurements: (nBu4N)[Cr(NCS)4(NH3)2]: monoclinic, C2/c (no. 15), a = 12.0818(8), b = 10.2425(8), c = 24.222(2) A, β = 98.324(3)°, Z = 4, R1(F)/wR2(F2) = 0.0332/0.0871; (C12H25)4N}[Cr(NCS)4(NH3)2]·0.85H2O: triclinic, P (no. 2), a = 8.4049(1), b = 20.1525(4), c = 20.7908(4) A, α = 67.487(1)°, β = 81.328(1)°, γ = 78.040(1)°, Z = 2, R1(F)/wR2(F2) = 0.0533/0.1343; (EMIm)[Cr(NCS)4(NH3)2]: orthorhombic, Pbcm (no

  一系列 9 种新型 Reineckate 盐，A[CrIII(NCS)4(NH3)2] 与各种大有机阳离子 A = 四烷基铵，[R4N]+，R = 正丁基，正十二烷基；1-烷基-3-甲基咪唑鎓，(RMIm)+：R = 甲基、乙基、异丙基、正丁基和正己基；合成了 A = 1,3-二甲基-2,4,5-三苯基咪唑鎓和 A = 1,2,3,4,5-五甲基咪唑鎓。测量每种化合物的熔点以查看是否有任何属于具有低熔点的含金属离子液体组。通过元素分析、NMR、IR和UV/Vis光谱进一步表征每种化合物。使用 Evans 方法从 NMR 研究得出有关磁行为的信息。已经发现，每种化合物都是顺磁性的，具有仅自旋 CrIII 的有效磁矩。具有 A = 四正丁基铵的 Reineckates 的结构，四正十二烷基铵、1-乙基-3-甲基咪唑鎓和 1,2,3,4,5-五甲基咪唑鎓通过单晶 X 射线衍射测量测定：(nBu4N)[Cr(NCS)4(
• Charge Generation in Low-Polarity Solvents: Poly(ionic liquid)-Functionalized Particles
  作者：Ghulam Hussain、Amy Robinson、Paul Bartlett

  DOI：10.1021/la3049086

  日期：2013.4.2

  We present a straightforward strategy for the synthesis of highly charged poly(ionic liquid)-functionalized particles in low-polarity solvents. A series of cationic liquid monomers consisting of a tetraalkyl ammonium cation and a fluorinated tetrakis[phenyl] borate anion linked, via a C3-alkyl chain, to a methacrylate unit were synthesized. The addition of this ionic monomer to a conventional dispersion

  我们提出了一种在低极性溶剂中合成高电荷聚（离子液体）功能化颗粒的直接策略。一系列阳离子液体单体，由四烷基铵阳离子和氟化四[苯基]硼酸根阴离子通过C 3连接而成合成到甲基丙烯酸酯单元的-烷基链。将这种离子单体添加到甲基丙烯酸甲酯和甲基丙烯酸的常规分散聚合中，在80°C的十二烷/己烷混合溶剂中进行分散，得到球形，高度单分散的颗粒，平均粒径在约50至2500 nm之间，具有高的电泳迁移率和稳定性在非极性溶剂（如十二烷）中。通过改变离子单体与甲基丙烯酸酯单体的比例，可以将十二烷中的表面电势调节在0至180±9 mV的范围内。这些粒子为纳米粒子和非极性环境中的有组织结构的静电组装开辟了新的机会。
• Process for Preparing Primary Intermediates for Dyeing Keratin Fibers
  申请人：The Procter & Gamble Company

  公开号：US20140121414A1

  公开（公告）日：2014-05-01

  A process has been developed for preparing 2-methoxymethyl-1,4-benzenediamine (IV-a), other compounds of formula (IV), and the salts thereof, all of which may be used as primary intermediates in compositions for dyeing keratin fibers.

  已开发出一种用于制备2-甲氧甲基-1,4-苯二胺（IV-a）、化学式（IV）的其他化合物及其盐的方法，所有这些化合物都可用作染发角蛋白纤维组合物中的主要中间体。
• DRUG DELIVERY MEDICAL DEVICE
  申请人：Micell Technologies, Inc.

  公开号：US20140371717A1

  公开（公告）日：2014-12-18

  A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

  公开了一种释放药物剂量到目标部位的医疗设备。该医疗设备包括一个气球，以及气球至少一部分的涂层。药物剂量的每个颗粒都至少部分地被聚合物层包裹。该方法包括以下步骤：提供一个包括气球和气球至少一部分的涂层的设备，涂层包括药物剂量的颗粒，每个药物剂量的颗粒都至少部分地被聚合物层包裹；将该设备定位到允许气球到达目标部位；以及充气该设备的气球。
• [EN] METHODS OF SYNTHESIZING 2-METHOXYMETHYL-1,4-BENZENEDIAMINE<br/>[FR] PROCÉDÉS DE SYNTHÈSE DE 2-MÉTHOXYMÉTHYL-1,4-BENZÈNEDIAMINE
  申请人：PROCTER & GAMBLE

  公开号：WO2012044758A1

  公开（公告）日：2012-04-05

  Disclosed is a method of making 2-methoxymethyl-1,4-benzenediamine that includes hydrogenating 1-benzylamino-2-(methoxymethyl)-4-nitrobenzene in the presence of a hydrogenation catalyst.

  揭示了一种制备2-甲氧甲基-1,4-苯二胺的方法，其中包括在氢化催化剂存在下氢化1-苄基氨基-2-(甲氧甲基)-4-硝基苯。