4,6-difluororesorcinol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4,6-difluororesorcinol
• 英文别名: 4,6-difluorobenzene-1,3-diol
• 化学式: C₆H₄F₂O₂
• 分子量: 146.093
• InChiKey: OEPHFJHSCASUKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间苯二酚 在 Selectfluor 、 1-正丁基-3-甲基咪唑三氟甲烷磺酸盐 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以70%的产率得到4-氟间苯二酚
  参考文献：
  名称：

  Promotional effect of ionic liquids in electrophilic fluorination of phenols

  摘要：

  The influence of a stoichiometric amount of ionic liquids (IL) on the fluorination of phenols in various solvents has been studied. The fluorination of phenol, 1-naphthol and resorcinol was carried out using 1-chloromethyl-4-fluoro-l,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (F-TEDA-BF4, Selectfluor (TM)) with the formation of 2-fluoro-, 4-fluorophenol, 2-fluoro-, 4-fluoronaphthol and 4-fluoro-, 4,6-difluoro-benzene-l,3-diol as the main products. The use of a stoichiometric amount of ionic liquid as an additive results in acceleration of the reactions. The effect is most significant at low temperatures. It has been found that solvent polarity has an essential effect on the difference in yields of fluoroproducts obtained in the presence of IL and without it.

  DOI：

  10.24820/ark.5550190.p010.164

文献信息

• Ethylened polymer and molded object obtained therefrom
  申请人：Satoh Yasuo

  公开号：US20060135712A1

  公开（公告）日：2006-06-22

  An ethylene-based polymer which is an ethylene/C4 to C10 α-olefin copolymer and satisfies the following requirements [k1] to [k3]: [k1] melt flow rate (MFR) under a loading of 2.16 kg at 190° C. is in the range of 1.0 to 50 g/10 minutes; [k2] LNR defined as a scale of neck-in upon film molding is in the range of 0.6 to 1.4; and [k3] take-up speed at break [DS (m/min)] at 160° C. and melt flow rate (MFR) satisfy the following relationship (Eq-1): 12×MFR 0.577 ≦DS≦165×MFR 0.577 (Eq-1), and a thermoplastic resin composition containing the ethylene-based polymer, provide a molded product, preferably a film, excellent in moldability and mechanical strength. The ethylene-based polymer can be efficiently obtained by polymerization in the presence of an olefin polymerization catalyst formed from a solid carrier, (A) a solid transition metal catalyst component obtained by contacting (a) a compound of a transition metal of the group 4 in the periodic table, containing at least one ligand having a cyclopentadienyl skeleton, (b) an organoaluminum oxy compound, (c) a multifunctional organic halide, and if necessary (d) an organoaluminum compound, and if necessary (B) organoaluminum compound.

  一种乙烯基聚合物，它是一种乙烯/C4 至 C10 α-烯烃共聚物，并满足以下[k1]至[k3]的要求：[k1] 熔体流动速率（MFR）在 190 摄氏度、负载 2.16 千克的条件下，范围在 1.0 至 50 克/10 分钟之间；[k2] LNR 定义为薄膜成型时的缩颈比例，范围在 0.6 至 1.4 之间；以及 [k3] 160 摄氏度时的断裂收口速度[DS（米/分）]和熔体流动速率（MFR）满足以下关系式（公式-1）：12×MFR 0.577 ≦DS≦165×MFR 0.577 (式-1），以及含有乙烯基聚合物的热塑性树脂组合物，可提供模塑产品，最好是薄膜，具有优异的模塑性和机械强度。乙烯基聚合物可通过在由固体载体、(A)固体过渡金属催化剂组分、(B)有机铝氧化合物、(C)多功能有机卤化物和必要时(D)有机铝化合物以及必要时(B)有机铝化合物形成的烯烃聚合催化剂存在下进行聚合而有效地获得。
• Synthesis, Properties, and Reactivity of <i>N,N</i>‘-Difluorobipyridinium and Related Salts and Their Applications as Reactive and Easy-To-Handle Electrophilic Fluorinating Agents with High Effective Fluorine Content¹
  作者：Teruo Umemoto、Masayuki Nagayoshi、Kenji Adachi、Ginjiro Tomizawa

  DOI：10.1021/jo972338q

  日期：1998.5.1

  N,N'-Difluoro-2,2'-, -2,4'-, -3,3'-, -4,4'-bipyridinium and substituted N,N'-difluoro-2,2'-bipyridinium bis(triflates), bis(tetrafluoroborates), bis(hexafluorophosphates), and bis(hexafluoroantimonates) 1-9 were synthesized in high yields by the direct fluorination of a mixture of a bipyridyl and a Lewis acid, a Bronsted acid, or the alkali metal salt of an acid. The higher homologues, trimer 10 and polymer II, were also synthesized. Unsubstituted or electron-donating group-substituted N,N'-difluorobipyridinium salts are stable nonhygroscopic crystals, while the electron-withdrawing group-substituted N,N'-diflurobipyridinium salts 3, 5, and 6 are moisture-sensitive crystals. Hydrolysis of Ib in boiling water gave 3,3'-dihydroxy-2,2'-bipyridyl. The reactivity determination indicated that the fluorinating capability decreased in the order 2,2'- much greater than 2,4' > 3,3'- approximate to 4,4'-isomer much greater than N-fluoropyridinium salt and that the two N-F moieties in a molecule mere effective for fluorination. This fluorination occurred in a step-by-step manner, and the reactivity difference between the first and second fluorinations was very small. N,N'-Difluoro-2,2'-bipyridinium bis(tetrafluoroborate) (Ib) is thus shown to be a highly reactive and easy-to-handle electrophilic fluorinating agent with the high effective fluorine content (103.3 g/kg) for preparing many fluoro organic compounds.
• Fluorination of aromatic compounds with N-fluorobenzenesulfonimide under solvent-free conditions
  作者：R. V. Andreev、G. I. Borodkin、V. G. Shubin

  DOI：10.1134/s107042800910008x

  日期：2009.10

  Reactions of N-fluorobenzenesulfonimide with methylbenzenes, phenols, and phenol ethers were studied under solvent-free conditions. The rate constant ratio for the reactions with mesitylene and durene indicates polar mechanism of the process. Solvent-free fluorination of aromatic compounds with N-fluorobenzenesulfonimide in some cases is more selective than reactions with other N-F reagents in a solvent.
• US7208559B2
  申请人：——

  公开号：US7208559B2

  公开（公告）日：2007-04-24