quinoxaline-2-carboxylic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: quinoxaline-2-carboxylic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide
• 英文别名: N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)naphthalen-1-yl]quinoxaline-2-carboxamide
• 化学式: C₂₂H₁₃F₆N₃O₂
• 分子量: 465.355
• InChiKey: LYQFSCINIZRVRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  75.1
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  1-Amino-2-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)naphthalene 、 2-喹喔啉甲酰氯 反应 22.0h， 以This provided the titled compound (33 mg, 11%)的产率得到quinoxaline-2-carboxylic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide
  参考文献：
  名称：

  Naphthalene amides as potassium channel openers

  摘要：

  本发明涉及化合物及其作为钾通道开放剂的能力。

  公开号：

  US20030199578A1

文献信息

• Structure–activity relationship of a novel class of naphthyl amide KATP channel openers
  作者：Sean C Turner、William A Carroll、Tammie K White、Michael E Brune、Steven A Buckner、Murali Gopalakrishnan、Adebola Fabiyi、Michael J Coghlan、Victoria E Scott、Neil A Castle、Anthony V Daza、Ivan Milicic、James P Sullivan

  DOI：10.1016/s0960-894x(03)00205-1

  日期：2003.5

  We have discovered a novel series of N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl] amides that are potent openers of K-ATP channels and investigated structure-activity relationships (SAR) around the 1,2-disubstituted naphthyl core. A-151892, a prototype compound of this series, was found to be a potent and efficacious potassium channel opener in vitro in transfected Kir6.2/SUR2B cells and pig bladder strips. Additionally, A-151892 was found to selectively inhibit unstable bladder contractions in vivo in an obstructed rat model of myogenic bladder function. (C) 2003 Elsevier Science Ltd. All rights reserved.