(E)-4-chloro-N'-(2-hydroxy-4-methoxybenzylidene)benzohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (E)-4-chloro-N'-(2-hydroxy-4-methoxybenzylidene)benzohydrazide
• 英文别名: 4-chloro-N-[(E)-(2-hydroxy-4-methoxyphenyl)methylideneamino]benzamide
• 化学式: C₁₅H₁₃ClN₂O₃
• 分子量: 304.733
• InChiKey: RJOZMOUMDNJCIK-RQZCQDPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  70.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-4-chloro-N'-(2-hydroxy-4-methoxybenzylidene)benzohydrazide 、 二氯双[(2-氯苯基)甲基]锡烷 以 甲醇 为溶剂， 反应 3.5h， 以87%的产率得到[N-(4-methoxy-2-oxidobenzylidene)-4-chlorobenzyhydrazidato]di(o-chlorobenzyl)tin(IV)
  参考文献：
  名称：

  Synthesis, spectral characterization and crystal structures of benzyltin complexes with (E)-4-chloro-N′-(2-hydroxy-4-methoxybenzylidene)benzohydrazide

  摘要：

  The reactions of the Schiff base ligand (E)-4-chloro-N'-(2-hydroxy-4-methoxybenzylidene)benzohydrazide (L) with substituted dibenzyltin dichlorides yielded a series of monobenzyltin complexes with the general formula (RC7H6)Sn(L)(S)Cl, where R = p-CH3, p-Cl, H, p-F, p-Br, o-CH3, o-F and S = H2O, methanol. An exception to this was obtained for the reaction with di(o-chlorobenzyl)tin dichloride, in which the di(o-chlorobenzyl)tin complex, (o-ClC7H6)(2)Sn(L) was the sole product. An attempt to displace the solvent molecule in the monobenzyltin complexes with 4,4,-bipyridine resulted in a mixture of products, containing a co-crystal of the methanol coordinated monobenzyltin complex and 4,4-bipyridine, (RC7H6)-Sn(L)(CH3OH)Cl center dot 4,4-bipyridine, and a six-coordinated dibenzyltin complex, (RC7H6)(2)Sn(L)Cl center dot CH3OH. If the donor ligand 4,4'-bipyridine or 4,4'-bipyridine N,N'-dioxide (L') was added in-situ during the preparation of the benzyltin complexes, either a dibenzyltin complex, (RC7H6)(2)Sn(L), or a binuclear dibenzyltin complex with the donor ligand (L'), (RC7H6)(2)SnCl2(L') [R = p-F], was obtained. Interestingly, both cis- and trans-(RC7H6)(2)SnCl2(L') complexes could be formed, as evidenced from their crystal structures. The structural formula of all the products were confirmed by elemental analysis, IR, H-1 and C-13 NMR spectroscopic studies and by X-ray analysis. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2014.06.043
• 作为产物：
  描述：

  2-羟基-4-甲氧基苯甲醛 、 4-氯苯甲酰肼 以 N,N-二甲基甲酰胺 为溶剂， 生成 (E)-4-chloro-N'-(2-hydroxy-4-methoxybenzylidene)benzohydrazide
  参考文献：
  名称：

  Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

  摘要：

  A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.058

文献信息

• SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER
  申请人：Young David H.

  公开号：US20120010075A1

  公开（公告）日：2012-01-12

  The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of fungi.

  本发明涉及使用含有肼化合物和铜的混合物来控制真菌生长。
• USE OF METAL HYDRAZIDE COMPLEX COMPOUNDS AS OXIDATION CATALYSTS
  申请人：BASF SE

  公开号：EP3524347A1

  公开（公告）日：2019-08-14

  The present invention relates to the use of selected metal complex compounds as oxidation catalysts as well as to a process for removing stains and soil on textiles and hard surfaces. The metal complex compounds have hydrazide ligands, preferably with electron withdrawing groups in the phenyl ring adjacent to the acyl group. Further aspects of the invention are formulations comprising such metal complex compounds, novel metal complex compounds and novel ligands.

  本发明涉及使用选定的金属络合物作为氧化催化剂，以及去除纺织品和硬表面污渍和污垢的工艺。金属络合物具有酰肼配体，最好是在邻近酰基的苯基环上具有取电子基团。本发明的其他方面是包含此类金属络合物、新型金属络合物和新型配体的制剂。
• USE OF HYDRAZIDE COMPOUNDS AS OXIDATION CATALYSTS
  申请人：BASF SE

  公开号：EP2271426B1

  公开（公告）日：2019-02-20
• Use of Metal Hydrazide Complex Compounds as Oxidation Catalysts
  申请人：BASF SE

  公开号：US20130281353A1

  公开（公告）日：2013-10-24

  The present invention relates to the use of selected metal complex compounds and ligands as oxidation catalysts as well as to a process for removing stains and soil on textiles and hard surfaces. The metal complex compounds have hydrazide ligands, preferably with electron withdrawing groups in the phenyl ring adjacent to the acyl group. Further aspects of the invention are formulations comprising such metal complex compounds, novel metal complex compounds and novel ligands.
• US8492324B2
  申请人：——

  公开号：US8492324B2

  公开（公告）日：2013-07-23