(1R,2R)-N,N'-bis(1H,1H,2H,2H-perfluorodecyl)cyclohexane-1,2-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1R,2R)-N,N'-bis(1H,1H,2H,2H-perfluorodecyl)cyclohexane-1,2-diamine
• 英文别名: (1R,2R)-1-N,2-N-bis(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)cyclohexane-1,2-diamine
• 化学式: C₂₆H₂₀F₃₄N₂
• 分子量: 1006.4
• InChiKey: RLVAKKWPJWRPEZ-NXEZZACHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13
• 重原子数：
  62
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  36

反应信息

• 作为产物：
  描述：

  1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-十七氟-10-碘庚烷 、 (1R,2R)-1,2-diaminocyclohexane 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 48.0h， 生成 (1R,2R)-N,N'-bis(1H,1H,2H,2H-perfluorodecyl)cyclohexane-1,2-diamine
  参考文献：
  名称：

  Fluorous derivatives of (1R,2R)-diaminocyclohexane as chiral ligands for metal-catalyzed asymmetric reactions

  摘要：

  Perfluoroalkyl-substituted, enantiopure diamines derived from (1R,2R)-diaminocyclohexane were conveniently prepared from readily available precursors. In situ generated metal complexes of these ligands were tested as chiral catalysts in three standard asymmetric reactions (cyclopropanation of styrene, hydrogen transfer reduction of acetophenone, and allylic alkylation of 1,3diphenyl-2-propenyl acetate) affording enantioselectivities of up to 47% in the copper-catalyzed cyclopropanation of styrene. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.05.040

文献信息

• Fluorous derivatives of (1R,2R)-diaminocyclohexane as chiral ligands for metal-catalyzed asymmetric reactions
  作者：Jerome Bayardon、Denis Sinou、Orsolya Holczknecht、Lászlo Mercs、Gianluca Pozzi

  DOI：10.1016/j.tetasy.2005.05.040

  日期：2005.7

  Perfluoroalkyl-substituted, enantiopure diamines derived from (1R,2R)-diaminocyclohexane were conveniently prepared from readily available precursors. In situ generated metal complexes of these ligands were tested as chiral catalysts in three standard asymmetric reactions (cyclopropanation of styrene, hydrogen transfer reduction of acetophenone, and allylic alkylation of 1,3diphenyl-2-propenyl acetate) affording enantioselectivities of up to 47% in the copper-catalyzed cyclopropanation of styrene. (c) 2005 Elsevier Ltd. All rights reserved.