1-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-amine
• 英文别名: 1-(1-Methylpyrazol-4-yl)indazol-3-amine；1-(1-methylpyrazol-4-yl)indazol-3-amine
• 化学式: C₁₁H₁₁N₅
• 分子量: 213.242
• InChiKey: LEMNKLSMALWULB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  61.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-甲基-4-溴吡唑 、 3-氨基吲唑 在 copper(l) iodide 、 (1R,2R)-(-)-N,N'-二甲基-1,2-环己二胺 、 potassium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 18.0h， 以64%的产率得到1-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-amine
  参考文献：
  名称：

  Copper‐Catalyzed N ¹ Coupling of 3‐Aminoindazoles and Related Aminoazoles with Aryl Bromides

  摘要：

  AbstractThe N1‐selective arylation of 3‐aminoindazoles using copper catalysis is herein reported. The reaction uses readily accessible aryl bromides as coupling partners, including those from heterocycles, and allows easy access to a broad variety of substituted 3‐aminoindazoles. The methodology was also examined on other aminoazoles of interest for the pharmaceutical industry.

  DOI：

  10.1002/ejoc.202101245

文献信息

• [EN] INDAZOLE AND AZAINDAZOLE BTK INHIBITORS<br/>[FR] INHIBITEURS DE LA BTK DE TYPE INDAZOLE ET AZAINDAZOLE
  申请人：MERCK SHARP & DOHME

  公开号：WO2016161571A1

  公开（公告）日：2016-10-13

  The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R7, R8 and R9 are as herein described. The present invention also provides pharmaceutical compositions comprising these compounds and methods for their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
• Copper‐Catalyzed <i>N</i> ¹ Coupling of 3‐Aminoindazoles and Related Aminoazoles with Aryl Bromides
  作者：Patrick Cyr、Eve‐Marline Joseph‐Valcin、Patrick Boissarie、Bruno Simoneau、Anne Marinier

  DOI：10.1002/ejoc.202101245

  日期：2022.1.27

  AbstractThe N1‐selective arylation of 3‐aminoindazoles using copper catalysis is herein reported. The reaction uses readily accessible aryl bromides as coupling partners, including those from heterocycles, and allows easy access to a broad variety of substituted 3‐aminoindazoles. The methodology was also examined on other aminoazoles of interest for the pharmaceutical industry.