(±)-sec-butylhydrazine hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (±)-sec-butylhydrazine hydrochloride
• 英文别名: 1-Sec-butylhydrazine hydrochloride；butan-2-ylhydrazine;hydrochloride
• 化学式: C₄H₁₂N₂*ClH
• mdl: MFCD13806973
• 分子量: 124.614
• InChiKey: MAOHZRUELSGCPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.49
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (±)-sec-butylhydrazine hydrochloride 生成 盐酸
  参考文献：
  名称：

  Taipale; Ussatschew, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1930, vol. 62, p. 1245

  摘要：

  DOI：
• 作为产物：
  描述：

  盐酸 、 乙醇 、 [2,2']偶氮丁烷 生成 (±)-sec-butylhydrazine hydrochloride
  参考文献：
  名称：

  Taipale; Ussatschew, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1930, vol. 62, p. 1245

  摘要：

  DOI：

文献信息

• A Variation of the Fischer Indolization Involving Condensation of Quinone Monoketals and Aliphatic Hydrazines
  作者：Jinzhu Zhang、Zhiwei Yin、Patrick Leonard、Jing Wu、Kate Sioson、Che Liu、Robert Lapo、Shengping Zheng

  DOI：10.1002/anie.201207533

  日期：2013.2.4

  new twist: A one‐pot nitrous acid free, diazonium‐free, and transition‐metal‐free variation of the Fischer indole synthesis has been developed. Condensation of quinone monoketals and aliphatic hydrazine hydrochlorides afforded indoles via intermediate alkylaryldiazenes. This method will complement the classical Fischer indole synthesis by providing indoles in two steps from widely available phenols

  一个新的转折：已开发出Fischer吲哚合成的一锅无亚硝酸，无重氮和无过渡金属的变体。醌单缩酮和脂族肼盐酸盐的缩合通过中间体烷基芳基二氮烯得​​到吲哚。该方法将在温和的条件下从两步制得的苯酚中分两步提供吲哚，从而补充了经典的Fischer吲哚合成方法。
• GB836332
  申请人：——

  公开号：——

  公开（公告）日：——
• Discovery and Characterization of 1<i>H</i>-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators
  作者：Joshua M. Wieting、Anish K. Vadukoot、Swagat Sharma、Kristopher K. Abney、Thomas M. Bridges、J. Scott Daniels、Ryan D. Morrison、Kevin Wickman、C. David Weaver、Corey R. Hopkins

  DOI：10.1021/acschemneuro.7b00217

  日期：2017.9.20

  The G protein-gated inwardly-rectifying potassium channels (GIRK, KO) are a family of inward-rectifying potassium channels, and there is significant evidence supporting the roles of GIRKs in a number of physiological processes and as potential targets for numerous indications. Previously reported urea containing molecules as GIRK1/2 preferring activators have had significant pharmacokinetic (PK) liabilities. Here we report a novel series of 1H-pyrazolo-5yl-2-phenylacetamides in an effort to improve upon the PK properties. This series of compounds display nanomolar potency as GIRK1/2 activators with improved brain distribution (rodent K-p > 0.6).