1-(1,4-dihydroxy-3-methoxy-naphthalen-2-yl)-butan-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(1,4-dihydroxy-3-methoxy-naphthalen-2-yl)-butan-1-one
• 英文别名: 1-(1,4-dihydroxy-3-methoxynaphthalen-2-yl)butan-1-one
• 化学式: C₁₅H₁₆O₄
• 分子量: 260.29
• InChiKey: WYUUSPXPJXWZHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.24
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  66.76
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-甲氧基-1,4-萘醌 、 正丁醛 以 苯 为溶剂， 反应 12.0h， 以24%的产率得到1-(1,4-dihydroxy-3-methoxy-naphthalen-2-yl)-butan-1-one
  参考文献：
  名称：

  Photoacylations of 2-substituted 1,4-naphthoquinones: a concise access to biologically active quinonoid compounds

  摘要：

  Photochemical acylations of 2-substituted-1,4-naphthoquinones with various aldehydes furnished acylated hydroquinones and acylated quinones in moderate to good combined yields. All reactions are easily performed and open a rapid access to biologically active compounds. For the 2-methyl-1,4-naphthoquinone/butyraldehyde pair, a novel tri-keto compound has been additionally isolated. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.12.060

文献信息

• Photoacylations of 2-substituted 1,4-naphthoquinones: a concise access to biologically active quinonoid compounds
  作者：Prashant A. Waske、Jochen Mattay、Michael Oelgemöller

  DOI：10.1016/j.tetlet.2005.12.060

  日期：2006.2

  Photochemical acylations of 2-substituted-1,4-naphthoquinones with various aldehydes furnished acylated hydroquinones and acylated quinones in moderate to good combined yields. All reactions are easily performed and open a rapid access to biologically active compounds. For the 2-methyl-1,4-naphthoquinone/butyraldehyde pair, a novel tri-keto compound has been additionally isolated. (c) 2005 Elsevier Ltd. All rights reserved.