2-[(4-Bromo-2-fluorophenyl)methyl]phthalazin-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-[(4-Bromo-2-fluorophenyl)methyl]phthalazin-1-one
• 化学式: C₁₅H₁₀BrFN₂O
• 分子量: 333.15
• InChiKey: BNICXKFXIBQVDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Process for the preparation of 3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazine-acetic acid
  申请人：Merck & Co., Inc.

  公开号：EP0322035A2

  公开（公告）日：1989-06-28

  There is disclosed an improved process for the preparation of 3-[(4-bromo-2-fluorophenyl)­methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid. The process is significantly improved over the prior art process in preparing the product in a one-step process where the prior art required three steps. The instant process directly alkylates a phthalazine ring nitrogen in the presence of the acetic acid moiety without the necessity of protecting the carboxylic acid group as was necessary in the prior art preferred process. The product is useful for treating the progressive deterioration resulting from diabetes.

  本文揭示了一种改进的制备3-[(4-溴-2-氟苯基)甲基]-3,4-二氢-4-氧基-1-菲噻嗪乙酸的工艺。该工艺相对于先前的工艺有显著改进，能够在一个步骤中制备出产品，而先前的工艺需要三个步骤。本工艺直接在醋酸基团的存在下烷基化菲噻嗪环中的氮原子，无需像先前的优选工艺中那样保护羧酸基团。该产品可用于治疗糖尿病引起的渐进性恶化。
• Process for the preparation of 3-[(4-bromo-2-fluorophenyl) methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid
  申请人：Merck & Co., Inc.

  公开号：EP0397930A1

  公开（公告）日：1990-11-22

  There is disclosed an improved process for the preparation of 3-[(4-bromo-2-fluorophenyl)­methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid. The process is significantly improved over the prior art process in preparing the product in a one-step process where the prior art required three steps. The instant process directly alkylates a phthalazine ring nitrogen in the presence of the acetic acid moiety without the necessity of protecting the carboxylic acid group as was necessary in the prior art preferred process. The product is useful for treating the progressive deterioration resulting from diabetes.

  本文介绍了一种改进的方法，用于制备3-[(4-溴-2-氟苯基)甲基]-3,4-二氢-4-氧基-1-邻菲啉乙酸。该方法相对于先前的方法在制备该产品时显著改进，直接在醋酸基团存在的情况下，通过烷基化邻菲啉环中的氮原子来制备该产品，而无需像先前的方法中那样保护羧酸基团。该产品可用于治疗糖尿病导致的逐渐恶化。