2-(R)-phenyl-2-(1,2,3,6-tetrahydropyridin-1-yl)ethanol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(R)-phenyl-2-(1,2,3,6-tetrahydropyridin-1-yl)ethanol
• 英文别名: 1-(1-Phenyl-2-oxyethyl)-1,2,5,6-tetrahydropyridine；2-(3,6-dihydro-2H-pyridin-1-yl)-2-phenylethanol
• 化学式: C₁₃H₁₇NO
• 分子量: 203.284
• InChiKey: HNOGPCNQXOTWBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2,3,6-四氢吡啶 、 (S)-环氧苯乙烷 以 乙醇 为溶剂， 以1.54 g (91.1%)的产率得到2-(R)-phenyl-2-(1,2,3,6-tetrahydropyridin-1-yl)ethanol
  参考文献：
  名称：

  Hydroxamic acid anesthetic compounds

  摘要：

  以下式的化合物：##STR1##及其药用可接受的盐，其中R.sup.1和R.sup.2独立地为氢、C.sub.1-4烷基、C.sub.3-7环烷基、C.sub.2-4烯基、C.sub.1-4烷氧基、C.sub.1-4烷硫基、苯基或苯基-C.sub.1-4烷基；或者R.sup.1和R.sup.2与它们连接的氮一起取代，并形成可选择取代的饱和或不饱和的含有一到两个杂原子的3、4、5、6或7元杂环，前提是这种杂环不是吡咯烷基；R.sup.3为氢、C.sub.1-4烷基或羟基保护基；Ar为苯基，可选择地取代为来自卤素、羟基、C.sub.1-4烷基、C.sub.1-4烷氧基、C.sub.1-4烷氧基-C.sub.1-4烷氧基、CF.sub.3和羧基-C.sub.1-4烷氧基的一个或多个取代基；X为苯基、萘基、联苯基、茚基、苯并呋喃基、苯并噻吩基、1-四氢基-6-基、C.sub.1-4烷二氧基、吡啶基、呋喃基或噻吩基，这些基可选择地取代为多达三个取代基。这些化合物和含有它们的药物组合物可用作镇痛、抗炎、利尿、止咳、麻醉或神经保护剂，或者用作治疗腹痛等功能性肠道疾病的药物，用于治疗哺乳动物受体，特别是人类受体。

  公开号：

  US05837717A1

文献信息

• Hydroxamic acid compounds as opioid kappa receptor agonists
  申请人：PFIZER INC.

  公开号：EP0789021A1

  公开（公告）日：1997-08-13

  A compound of the following formula: and its pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, C2-4 alkenyl, C1-4 alkoxy-C1-4 alkyl, C1-4 alkylthio-C1-4 alkyl, phenyl, phenyl-C1-4alkyl, halo-substituted C1-4 alkyl, C3-7 cycloalkyl-C1-3 alkyl or hydroxy-C1-4alkyl ; or R1 and R2 are taken together with the nitrogen to which they are attached and form optionally substituted, saturated or unsaturated 3-, 4-, 5-, 6- or 7- membered heterocyclic cantaining one to two heteroatoms, provided that the heterocyclic is not pyrrolidinyl; R3 ishydrogen, C1-4 alkyl or a hydroxy protecting group; Ar isoptionally substituted phenyl or phenyl-C1-3 alkyl; and X isoptionally substituted phenyl, naphthyl, biphenyl, indanyl, benzofuranyl, benzothiophenyl, 1-tetralone-6-yl, C1-4 alkylenedioxy, pyridyl, furyl or thienyl. These compounds and pharmaceutical compositions containing them are useful as analgesic, antiinflammatory, diuretic, antitussive, anesthetic or neuroprotective agents, or an agent for treatment of stroke or functional bowel disease such as abdominal pain, for the treatment of a mammalian subject, especially a human subject.

  下式化合物 及其药学上可接受的盐，其中 R1 和 R2 独立地为氢、C1-4 烷基、C3-7 环烷基、C2-4 烯基、C1-4 烷氧基-C1-4 烷基、C1-4 硫代烷基-C1-4 烷基、苯基、苯基-C1-4 烷基、卤代 C1-4 烷基、C3-7 环烷基-C1-3 烷基或羟基-C1-4 烷基；或 R1 和 R2 与它们所连接的氮一起形成任选取代的、饱和或不饱和的 3-、4-、5-、6-或 7-成员杂环，其中含有一至两个杂原子，条件是该杂环不是吡咯烷基； R3 是氢、C1-4 烷基或羟基保护基团； Ar 是任选取代的苯基或苯基-C1-3 烷基；以及 X 是任选取代的苯基、萘基、联苯基、茚基、苯并呋喃基、苯并噻吩基、1-四氢萘-6-基、C1-4 烷二氧基、吡啶基、呋喃基或噻吩基。 这些化合物和含有它们的药物组合物可用作镇痛剂、抗炎剂、利尿剂、止咳剂、麻醉剂或神经保护剂，或治疗中风或功能性肠病（如腹痛）的药物，用于治疗哺乳动物，特别是人类。
• US5837717A
  申请人：——

  公开号：US5837717A

  公开（公告）日：1998-11-17
• Hydroxamic acid anesthetic compounds
  申请人：Pfizer Inc.

  公开号：US05837717A1

  公开（公告）日：1998-11-17

  A compound of the following formula: ##STR1## and its pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-4 alkenyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, phenyl or phenyl-C.sub.1-4 alkyl; or R.sup.1 and R.sup.2 are taken together with the nitrogen to which they are attached and form optionally substituted, saturated or unsaturated 3-, 4-, 5-, 6- or 7-membered heterocyclic cantaining one to two heteroatoms, provided that the heterocyclic is not pyrrolidinyl; R.sup.3 is hydrogen, C.sub.1-4 alkyl or a hydroxy protecting group; Ar is phenyl optionally substituted with one or more substituents selected from halo, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkoxy-C.sub.1-4 alkyloxy, CF.sub.3 and carboxy-C.sub.1-4 alkyloxy; and X is phenyl, naphthyl, biphenyl, indanyl, benzofuranyl, benzothiophenyl, 1-tetralone-6-yl, C.sub.1-4 alkylenedioxy, pyridyl, furyl or thienyl, these groups being optionally substituted with up to three substituents. These compounds and pharmaceutical compositions containing them are useful as analgesic, antiinflammatory, diuretic, antitussive, anesthetic or neuroprotective agents, or an agent for treatment of functional bowel disease such as abdominal pain, for the treatment of a mammalian subject, especially a human subject.

  以下式的化合物：##STR1##及其药用可接受的盐，其中R.sup.1和R.sup.2独立地为氢、C.sub.1-4烷基、C.sub.3-7环烷基、C.sub.2-4烯基、C.sub.1-4烷氧基、C.sub.1-4烷硫基、苯基或苯基-C.sub.1-4烷基；或者R.sup.1和R.sup.2与它们连接的氮一起取代，并形成可选择取代的饱和或不饱和的含有一到两个杂原子的3、4、5、6或7元杂环，前提是这种杂环不是吡咯烷基；R.sup.3为氢、C.sub.1-4烷基或羟基保护基；Ar为苯基，可选择地取代为来自卤素、羟基、C.sub.1-4烷基、C.sub.1-4烷氧基、C.sub.1-4烷氧基-C.sub.1-4烷氧基、CF.sub.3和羧基-C.sub.1-4烷氧基的一个或多个取代基；X为苯基、萘基、联苯基、茚基、苯并呋喃基、苯并噻吩基、1-四氢基-6-基、C.sub.1-4烷二氧基、吡啶基、呋喃基或噻吩基，这些基可选择地取代为多达三个取代基。这些化合物和含有它们的药物组合物可用作镇痛、抗炎、利尿、止咳、麻醉或神经保护剂，或者用作治疗腹痛等功能性肠道疾病的药物，用于治疗哺乳动物受体，特别是人类受体。