(+)-萍蓬汀 | 468-89-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 中文名称: (+)-萍蓬汀
• 英文名称: nupharidine
• 英文别名: Nupharidin；(9aS)-4t-furan-3-yl-1c,7t-dimethyl-(9ar)-octahydro-quinolizine 5c-oxide；(1R,4S,5R,7S,9aS)-4-(furan-3-yl)-1,7-dimethyl-5-oxido-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-5-ium
• CAS: 468-89-3
• 化学式: C₁₅H₂₃NO₂
• 分子量: 249.353
• InChiKey: HISDAJRMKAJROU-PTNZTPPNSA-N

物化性质

• 熔点：
  221°
• 比旋光度：
  D +15°
• 沸点：
  127-128 °C(Press: 2.5 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+)-萍蓬汀 在 乙酸酐 作用下， 以 氯仿 为溶剂， 生成 6-dehydrodeoxynupharidine
  参考文献：
  名称：

  Polonovski transformation of (+)-nupharidine. Stereochemistry and utility in synthesis

  摘要：

  DOI：

  10.1021/ja00739a023

文献信息

• METHODS AND COMPOSITIONS FOR INHIBITING THE NUCLEAR FACTOR kB PATHWAY
  申请人：Ben Gurion University of The Negev Research And Development Authority

  公开号：EP2595991B1

  公开（公告）日：2017-04-26
• METHODS AND COMPOSITIONS FOR INHIBITING THE NUCLEAR FACTOR KAPPAB PATHWAY
  申请人：Golan Avi

  公开号：US20130122114A1

  公开（公告）日：2013-05-16

  The current invention provides therapeutic methods which include inhibition of nuclear factor κb pathway in a cell based on the discovery of an active fraction of a plant extract termed NUP or a composition which includes NUP. NUP is used in treating and managing different diseases such as cancer, inflammation, and virus infections.
• NUPHARIDINE COMPOUNDS AND DERIVATIVES THEREOF FOR THE TREATMENT OF CYSTEINE PROTEASE RELATED DISEASES
  申请人：B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY

  公开号：US20180360810A1

  公开（公告）日：2018-12-20

  Disclosed a method of treating a disease or a disorder characterized by protease activity. A pharmaceutical composition for treating a disease or a disorder characterized by protease activity is further disclosed. A method of detecting a cysteine protease from a biological sample is also disclosed.
• US4007277A
  申请人：——

  公开号：US4007277A

  公开（公告）日：1977-02-08
• US4011327A
  申请人：——

  公开号：US4011327A

  公开（公告）日：1977-03-08