(1S)-6,7-二甲氧基-1,2-二甲基-3,4-二氢-1H-异喹啉-5-醇 | 32829-58-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 中文名称: (1S)-6,7-二甲氧基-1,2-二甲基-3,4-二氢-1H-异喹啉-5-醇
• 英文名称: Gigantin
• 英文别名: Gigantine；(1S)-6,7-dimethoxy-1,2-dimethyl-3,4-dihydro-1H-isoquinolin-5-ol
• CAS: 32829-58-6
• 化学式: C₁₃H₁₉NO₃
• 分子量: 237.299
• InChiKey: HRJQUAXWKYISJC-QMMMGPOBSA-N

物化性质

• 熔点：
  151-152°
• 比旋光度：
  D25 +27.1° (c = 2 in chloroform)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933499090

文献信息

• RIBOTOXIN MOLECULES DERIVED FROM SARCIN AND OTHER RELATED FUNGAL RIBOTOXINS
  申请人：Research Corporation Technologies, Inc

  公开号：EP2971038A1

  公开（公告）日：2016-01-20
• COMPOSITIONS FOR TREATING OBSESSIVE-COMPULSIVE DISORDER
  申请人：Borody, Thomas Julius

  公开号：EP2991649B1

  公开（公告）日：2020-06-03
• METHODS OF SCREENING, SELECTING, AND IDENTIFYING CYTOTOXIC RECOMBINANT POLYPEPTIDES BASED ON AN INTERIM DIMINUTION OF RIBOTOXICITY
  申请人：Molecular Templates, Inc.

  公开号：EP3102245B1

  公开（公告）日：2021-09-08
• [EN] RIBOTOXIN MOLECULES DERIVED FROM SARCIN AND OTHER RELATED FUNGAL RIBOTOXINS<br/>[FR] MOLÉCULES DE RIBOTOXINES DÉRIVÉES DE SARCINE ET AUTRES RIBOTOXINES FONGIQUES ASSOCIÉES
  申请人：RES CORP TECHNOLOGIES INC

  公开号：WO2014158770A1

  公开（公告）日：2014-10-02

  The present application relates to modified T cell epitopes derived from fungal ribotoxins, including a-sarcin, clavin, gigantin, mitogillin, and restrictocin, as well as modified ribotoxin molecules comprising one or more of the modified epitopes. The modified ribotoxin molecules inhibit protein synthesis, like the wild type ribotoxins, but exhibit reduced immunogenicity as compared to the corresponding wild type ribotoxin. Another aspect relates to a fusion protein which comprises a modified ribotoxin fused or conjugated or otherwise linked to a targeting molecule that is effective for binding a target of interest. Another aspect relates to the use of the modified ribotoxin or fusion protein for treating or managing a disease or condition.