(1S,2S)-2-[(4R,11BS)-3,5-二氢-4H-二萘并[2,1-C:1',2'-E〕膦-4-基]-1,2-二苯基乙胺 | 1092064-02-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: (1S,2S)-2-[(4R,11BS)-3,5-二氢-4H-二萘并[2,1-C:1',2'-E〕膦-4-基]-1,2-二苯基乙胺
• 中文别名: (1S,2S)-2-[(4R,11BS)-3H-二萘并[2,1-C:1',2'-E]亚磷-4(5H)-基]-1,2-二苯基乙基胺, 97+%
• 英文名称: (1S,2S)-2-((S)-3H-dinaphtho[2,1-c:1',2'-e]phosphepin-4(5H)-yl)-1,2-diphenyl-ethanamine
• 英文别名: (1S,2S)-2-((4S)-3H-Dinaphtho[2,1-c:1',2'-e]phosphepin-4(5H)-yl)-1,2-diphenylethanamine；(1S,2S)-1,2-diphenyl-2-(13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-yl)ethanamine
• CAS: 1092064-02-2
• 化学式: C₃₆H₃₀NP
• 分子量: 507.615
• InChiKey: YHBAPPMVVCHAQC-ZPGRZCPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

SDS

---

Section 1: Product Identification
(1S,2S)-2-[(4R,11bS)-3,5-dihydro-4H-dinaphtho[2,1-c:1',2'-e]phosphepin-4-yl]-1,2-diphenylethanamine, min.
Chemical Name:
97%
CAS Registry Number: 1092064-02-2
Formula: C36H30NP
EINECS Number: none
Chemical Family: organophosphine ligand
Synonym: none

---

Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title compound 1092064-02-2 100% no data no data

---

Section 3: Hazards Identification
Emergency Overview: Irritating to skin, eyes and respiratory tract. May be harmful if swallowed.
Primary Routes of Exposure: Ingestion, inhalation
Eye Contact: Causes moderate irritation of the eyes.
Skin Contact: Causes slight to mild irritation of the skin.
Inhalation: Irritating to the nose, mucous membranes and respiratory tract.
Ingestion: No information available on the physiological effects of ingestion. May be harmful if swallowed.
Acute Health Affects: Irritating to skin, eyes and respiratory tract.
Chronic Health Affects: No information on long-term chronic effects.
NTP: No
IARC: No
OSHA: No

---

SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

---

SECTION 5: Fire Fighting Measures
Flash Point: no data
Autoignition Temperature: no data
Explosion Limits: no data
Extinguishing Medium: carbon dioxide, dry powder or foam
If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self-contained breathing apparatus and full protective clothing.
Hazardous Combustion and If involved in a fire this material may emit irritating fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

---

SECTION 6: Accidental Release Measures
Spill and Leak Procedures: Small spills can be mixed with vermiculite or sodium carbonate and swept up.

---

SECTION 7: Handling and Storage
Store in a tightly sealed container under an inert atmosphere of nitrogen or argon. Keep in a cool, dry, well
Handling and Storage:
ventilated place.

---

SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves.
Ventilation: Handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Handle the material in an efficient fume hood.
Additional Protection: No additional protection required.

---

SECTION 9: Physical and Chemical Properties
Color and Form: white solid
Molecular Weight: 507.6
Melting Point: no data
Boiling Point: no data
Vapor Pressure: no data
Specific Gravity: no data
Odor: none
Solubility in Water: Insoluble

---

SECTION 10: Stability and Reactivity
Stability: air sensitive
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: prolonged exposure to air
Incompatibility: strong oxidizing agents
Decomposition Products: carbon monoxide, carbon dioxide, nitrogen oxides, phosphorous oxides and organic fumes

---

SECTION 11: Toxicological Information
RTECS Data: No information available in the RTECS files
Carcinogenic Effects: No data
Mutagenic Effects: No data
Tetratogenic Effects: No data

---

SECTION 12: Ecological Information
Ecological Information: No information available

---

SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.

---

SECTION 14: Transportation
Shipping Name (CFR): Non-hazardous
Hazard Class (CFR): NA
Additional Hazard Class (CFR): NA
Packaging Group (CFR): NA
UN ID Number (CFR): NA
Shipping Name (IATA): Non-hazardous
Hazard Class (IATA): NA
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): NA

---

SECTION 15: Regulatory Information
TSCA: Not listed in the TSCA inventory
SARA (Title 313): Not reportable under SARA 313.
Second Ingredient: none

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  (1S,2S)-2-[(4R,11BS)-3,5-二氢-4H-二萘并[2,1-C:1',2'-E〕膦-4-基]-1,2-二苯基乙胺 在 tetrafluoroboric acid 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.5h， 以59%的产率得到(1S,2S)-2-((4R,11bS)-3H-dinaphtho[2,1-c:1',2'-e]phosphepin-4(5H)-yl)-1,2-diphenylethanammonium tetrafluoroborate
  参考文献：
  名称：

  METHOD FOR PREPARING A METAL CATALYST

  摘要：

  本公开涉及一种制备金属催化剂的方法，该方法包括至少一种通过至少一个磷（P）原子和至少一个氮（N）原子配位到金属的配体，所述方法包括在碱的存在下，将金属前体配合物与氨基膦、二氨基膦、氨基双膦或二氨基双膦的酸和盐反应。

  公开号：

  US20120046479A1
• 作为产物：
  描述：

  tert-butyl N-[(1S,2S)-1,2-diphenyl-2-(13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-yl)ethyl]carbamate 在 三氟乙酸 、 sodium carbonate 作用下， 以 二氯甲烷 、 水 为溶剂， 以72%的产率得到(1S,2S)-2-[(4R,11BS)-3,5-二氢-4H-二萘并[2,1-C:1',2'-E〕膦-4-基]-1,2-二苯基乙胺
  参考文献：
  名称：

  [EN] METHOD FOR THE PREPARATION OF AMINOPHOSPHINE LIGANDS AND THEIR USE IN METAL CATALYSTS
  [FR] PROCÉDÉ D'OBTENTION DE LIGANDS DE TYPE AMINOPHOSPHINE ET LEUR UTILISATION COMME CATALYSEURS MÉTALLIQUES

  摘要：

  公开号：

  WO2008148202A8

文献信息

• Rhodium-P,O-bidentate coordinated ureaphosphine ligands for asymmetric hydrogenation reactions
  作者：Jurjen Meeuwissen、Remko J. Detz、Albertus J. Sandee、Bas de Bruin、Joost N. H. Reek

  DOI：10.1039/b926043a

  日期：——

  We present new ureaphosphine ligands that coordinate in a P,O-bidentate fashion to rhodium(I). The ureaphosphine-Rh(I)-complexes were effectively used in the asymmetric hydrogenation of cyclic enamides giving high conversions and enantioselectivity.

  我们提出新的 脲膦以P，O-二齿形式与铑（I）配位的配体。这脲膦-Rh（I）-配合物可有效用于环状酰胺的不对称氢化，从而提供高转化率和对映选择性。
• Synthesis of Chiral Aminophosphines from Chiral Aminoalcohols via Cyclic Sulfamidates
  作者：Rongwei Guo、Shuiming Lu、Xuanhua Chen、Chi-Wing Tsang、Wenli Jia、Christine Sui-Seng、Dino Amoroso、Kamaluddin Abdur-Rashid

  DOI：10.1021/jo902302c

  日期：2010.2.5

  Protic aminophosphines with multiple chiral centers were synthesized in good yields and high purity by the nucleophilic ring-opening of N-protected cyclic sulfamidates with metal phosphides, followed by hydrolysis and deprotection. This synthetic approach is clean, scalable, and high yielding. The method provides an efficient alternative route for the synthesis of chiral aminophosphines.
• METHOD FOR THE PREPARATION OF AMINOPHOSPHINE LIGANDS AND THEIR USE IN METAL CATALYSTS
  申请人：Abdur-Rashid Kamaluddin

  公开号：US20100204514A1

  公开（公告）日：2010-08-12

  The present application is directed to i) a method for synthesizing aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands, ii) the use of such ligands in the preparation of metal complexes as hydrogenation catalysts, and iii) aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands of various structures. In particular, the methods in i) involve reacting a protected tertiary amine of formula (I) with a metal phosphide of the formula Y—PR8R9 to afford an aminophosphine of formula (II), which can then be optionally further reacted with a phosphine of the formula (III) to afford the phosphine-aminophosphine of formula (IV).
• US8658825B2
  申请人：——

  公开号：US8658825B2

  公开（公告）日：2014-02-25
• US8716508B2
  申请人：——

  公开号：US8716508B2

  公开（公告）日：2014-05-06