(1S-(1alpha,3beta,4abeta,10abeta))-3,4,5,10-四氢-5,10-二氧代-9-羟基-1-甲基-4a,10a-环氧-1H-萘并(2,3-c)吡喃-3-乙酸 | 72660-52-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 中文名称: (1S-(1alpha,3beta,4abeta,10abeta))-3,4,5,10-四氢-5,10-二氧代-9-羟基-1-甲基-4a,10a-环氧-1H-萘并(2,3-c)吡喃-3-乙酸
• 中文别名: 向日葵油,聚合异酞酸和三羟甲基丙烷
• 英文名称: Nanaomycin E
• 英文别名: 2-[(1R,10S,11S,13R)-7-hydroxy-11-methyl-2,9-dioxo-12,15-dioxatetracyclo[8.4.1.01,10.03,8]pentadeca-3(8),4,6-trien-13-yl]acetic acid
• CAS: 72660-52-7
• 化学式: C₁₆H₁₄O₇
• 分子量: 318.28
• InChiKey: SVGOJJZXRJJDLY-IUFZWFJJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (1S-(1alpha,3beta,4abeta,10abeta))-3,4,5,10-四氢-5,10-二氧代-9-羟基-1-甲基-4a,10a-环氧-1H-萘并(2,3-c)吡喃-3-乙酸 生成 七尾霉素
  参考文献：
  名称：

  OMURA, SATOSHI;TANAKA, HARUO;TAKAHASHI, ITARU;ISHII, SHINZO;MINEURA, KAZU+

  摘要：

  DOI：

文献信息

• Antibiotic nanaomycin E and a process for producing the same
  申请人：Kyowa Hakko Kogyo Kabushiki Kaisha

  公开号：US04296040A1

  公开（公告）日：1981-10-20

  The present invention teaches a new antibiotic nanaomycin E represented by the formula: ##STR1## Nanaomycin E is active against Gram-positive bacteria, Trichophyton and Mycoplasma and may be used as antibacterial and therapeutic agents for humans and animals. Nanaomycin E is also a useful starting maerial for the preparation of nanaomycin A which latter nanaomycin has the highest activity among the various nanaomycin-type compounds. Nanaomycin E is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing nanaomycin E, especially Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135) and recovering the same from the fermented liquor.

  本发明教授了一种新的抗生素nanaomycin E，其化学式为：##STR1## Nanaomycin E对革兰氏阳性菌、毛癣菌和支原体具有活性，并可用作人类和动物的抗菌和治疗剂。Nanaomycin E还是制备nanaomycin A的有用起始材料，后者是各种nanaomycin型化合物中活性最高的。Nanaomycin E是通过发酵属于链霉菌属的微生物并能够产生nanaomycin E，特别是Streptomyces rosa变种notoensis（FERM-P 2209; ATCC 31135）并从发酵液中回收而得到的。
• Process for producing antibiotic nanaomycin E
  申请人：Kyowa Hakko Kogyo Kabushiki Kaisha

  公开号：US04353986A1

  公开（公告）日：1982-10-12

  The present invention teaches a new antibiotic nanaomycin E represented by the formula: ##STR1## Nanaomycin E is active against Gram-positive bacteria, Trichophyton and Mycoplasma and may be used as antibacterial and therapeutic agents for humans and animals. Nanaomycin E is also a useful starting material for the preparation of nanaomycin A which latter nanaomycin has the highest activity among the various nanaomycin-type compounds. Nanaomycin E is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing nanaomycin E, especially Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135) and recovering the same from the fermented liquor.

  本发明教授了一种新的抗生素nanaomycin E，其化学式为：##STR1## Nanaomycin E对革兰氏阳性菌、毛癣菌和支原体具有活性，并可用作人类和动物的抗菌和治疗剂。Nanaomycin E也是制备nanaomycin A的有用起始材料，后者是各种nanaomycin型化合物中活性最高的一种。Nanaomycin E是通过发酵属于链霉菌属的微生物并能够产生nanaomycin E的菌株，特别是Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135)，并从发酵液中回收而得到的。
• OMURA, SATOSHI;TANAKA, HARUO;TAKAHASHI, ITARU;ISHII, SHINZO;MINEURA, KAZU+
  作者：OMURA, SATOSHI、TANAKA, HARUO、TAKAHASHI, ITARU、ISHII, SHINZO、MINEURA, KAZU+

  DOI：——

  日期：——