(2R)-N-[(1R,2R)-2-羟基-1,2-二苯乙基]-2-吡咯烷甲酰胺 | 948594-97-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: (2R)-N-[(1R,2R)-2-羟基-1,2-二苯乙基]-2-吡咯烷甲酰胺
• 中文别名: (2R,1′R,2′R)-吡咯烷-2-羧酸(2-羟基-1,2-二苯基-乙基)酰胺
• 英文名称: (R)-N-((1R,2R)-2-Hydroxy-1,2-diphenylethyl)pyrrolidine-2-carboxamide
• 英文别名: (2R)-N-[(1R,2R)-2-hydroxy-1,2-diphenylethyl]pyrrolidine-2-carboxamide
• CAS: 948594-97-6
• 化学式: C₁₉H₂₂N₂O₂
• 分子量: 310.4
• InChiKey: JVOUIFUIIPEWLM-KZNAEPCWSA-N

物化性质

• 熔点：
  127-131 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] STEREOSELECTIVE SYNTHESIS OF ENANTIOMERICALLY-ENRICHED PANTOLACTONE<br/>[FR] SYNTHÈSE STÉRÉOSÉLECTIVE DE PANTOLACTONE ENRICHIE EN ÉNANTIOMÈRES
  申请人：DSM IP ASSETS BV

  公开号：WO2019228874A1

  公开（公告）日：2019-12-05

  The present invention relates stereoselective synthesis of enantiomerically enriched pantolactone.

  本发明涉及对对映体富集的泛醇内酯进行立体选择性合成。
• Optical Resolution Method for Bicyclic Compound Using Asymmetric Catalyst
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20140296569A1

  公开（公告）日：2014-10-02

  An optically active bicyclic compound is efficiently produced by optical resolution using an optically active amine.

  使用光学分辨法，利用光学活性胺高效地制备了光学活性的双环化合物。
• STEREOSELECTIVE SYNTHESIS OF ENANTIOMERICALLY-ENRICHED PANTOLACTONE
  申请人：DSM IP Assets B.V.

  公开号：EP3819295A1

  公开（公告）日：2021-05-12

  The present invention relates stereoselective synthesis of enantiomerically enriched pantolactone of formula (I) or (I').

  本发明涉及式 (I) 或 (I') 对映体富集泛醇内酯的立体选择性合成。
• Metallorganocatalysis For Asymmetric Transformations
  申请人：RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

  公开号：US20160023198A1

  公开（公告）日：2016-01-28

  A ligand having the structure or its enantiomer; (I) wherein: each one of R a , R b , R c and R d is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH 2 NH; *CH(CH 3 )NH(C*,R); and the organocatalyst is an organic molecule catalyst covalently bound to the bridge group. Also, a catalyst having the structure or its enantiomer: (II) wherein: each one of R a , R b , R c and R d is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH 2 NH; *CH(CH 3 )NH(C*,R); and *CH(CH 3 )NH(C*,S); the organocatalyst is an organic molecule catalyst covalently bound to the bridge group; and M is selected from the group consisting of Rh, Pd, Cu, Ru, Ir, Ag, Au, Zn, Ni, Co, and Fe.
• US9035103B2
  申请人：——

  公开号：US9035103B2

  公开（公告）日：2015-05-19