4-[(E)-Hydrazinylidenemethyl]-N,N-dimethylaniline

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-[(E)-Hydrazinylidenemethyl]-N,N-dimethylaniline
• 化学式: C₉H₁₃N₃
• 分子量: 163.22
• InChiKey: XMEOVXDIXDRWLH-YRNVUSSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
  申请人：——

  公开号：US20020128292A1

  公开（公告）日：2002-09-12

  The present invention is directed to substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs thereof, represented by the general Formula I: 1 wherein X, Ar 1 , R 2 -R 6 and R 12 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

  本发明涉及取代的吲哚-2-羧酸亚苄基肼及其类似物，其由通式I表示： 1 其中X，Ar 1 ，R 2 -R 6 和R 12 的定义如本文中所述。本发明还涉及发现具有I式的化合物是半胱天冬酶的激活剂和凋亡的诱导剂。本发明的化合物可用于诱导在异常细胞不受控制的生长和扩散发生的多种临床状况中的细胞死亡。
• Combination of antioxidant substances for the treatment of alzheimer's disease
  申请人：Colba R & D Inc.

  公开号：US20030158237A1

  公开（公告）日：2003-08-21

  Disclosed is a pharmaceutical composition for the treatment of cognitive symptoms caused by Alzheimer's disease in a mammal. This composition comprising vitamin E, quercitin, caffeic acid, nicotinic acid or derivatives and/or analog thereof, and a pharmaceutically acceptable excipient.

  本发明公开了一种药物组合物，用于治疗由阿尔茨海默病引起的哺乳动物认知症状。该组合物包含维生素 E、槲皮素、咖啡酸、烟酸或其衍生物和/或类似物，以及药学上可接受的赋形剂。
• ENHANCEMENT OF LACCASE REACTIONS
  申请人：Novozymes A/S

  公开号：EP0707637B1

  公开（公告）日：2005-11-02
• HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR
  申请人：ASKA Pharmaceutical Co., Ltd.

  公开号：EP2594555B1

  公开（公告）日：2018-03-07
• HEME OXYGENASE INHIBITORS, SCREENING METHODS FOR HEME OXYGENASE INHIBITORS AND METHODS OF USE OF HEME OXYGENASE INHIBITORS FOR ANTIMICROBIAL THERAPY
  申请人：Wilks Angela

  公开号：US20100081661A1

  公开（公告）日：2010-04-01

  Inhibitors of microbial heme oxygenase and their use for treatment of microbial infections and bioremediation. The inhibitors of microbial heme oxygenase are useful against a new class of antimicrobial agents to target infections that are persistently difficult to combat with the current spectrum of antimicrobial agents. Screening methods for selecting inhibitors of microbial heme oxygenase.