N-(3-Hydroxy-4-methoxybenzylideneamino)-N'-hydroxyguanidine tosylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-(3-Hydroxy-4-methoxybenzylideneamino)-N'-hydroxyguanidine tosylate
• 英文别名: 1-hydroxy-2-[(E)-(3-hydroxy-4-methoxyphenyl)methylideneamino]guanidine;4-methylbenzenesulfonic acid
• 化学式: C₇H₈O₃S*C₉H₁₂N₄O₃
• 分子量: 396.424
• InChiKey: YNXZNJZUTSAYBH-HMXKFKBXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.48
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  175
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
  申请人：——

  公开号：US20040024060A1

  公开（公告）日：2004-02-05

  The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R1, R2, R3, R4 and R5 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and the pharmacologically active salts thereof. 1

  本发明涉及使用一般式（I）化合物作为黑色素皮质激素受体的配体和/或治疗黑色素皮质激素系统疾病的方法：其中X为H或OH；R1、R2、R3、R4和R5相同或不同，选择自氢，卤素，1至5个碳原子的烷基，电子给体基团，如1-5个碳原子的烷氧基或羟基，电子受体基团，选择自氰基，硝基，三氟烷基或酰胺；烷基氨基，苯甲酰氧基，硝基氧基，苯基或磺酸基；以及其药理活性盐。
• USE OF BENZYLIDENEAMINOGUANIDINES AND HYDROXYGUANIDINES AS MELANOCORTIN RECEPTOR LIGANDS
  申请人：Lundstedt Torbjörn

  公开号：US20110015437A1

  公开（公告）日：2011-01-20

  The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R1, R2, R3, R4 and R5 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and the pharmacologically active salts thereof.
• METHOD FOR TREATING ARTHRITIS
  申请人：LUNDSTEDT Torbjörn

  公开号：US20120178820A1

  公开（公告）日：2012-07-12

  The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R1, R2, R3, R4 and R5 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and the pharmacologically active salts thereof.
• METHOD OF TREATING INFLAMMATION
  申请人：AnaMar AB

  公开号：US20130295009A1

  公开（公告）日：2013-11-07

  The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R 1 , R 2 , R 3 , R 4 and R 5 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and the pharmacologically active salts thereof;
• US8148429B2
  申请人：——

  公开号：US8148429B2

  公开（公告）日：2012-04-03