(2S,3S,4R,2'R)-2-(2'-羟基二十四碳酰氨基)十八烷-1,3,4-三醇 | 154801-30-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 中文名称: (2S,3S,4R,2'R)-2-(2'-羟基二十四碳酰氨基)十八烷-1,3,4-三醇
• 英文名称: (2S,3S,4R)-2-<(2R)-2-hydroxytetracosanoylamino>-1,3,4-octadecanetriol
• 英文别名: (2S,3S,4R)-2-[(2'R)-2'-hydroxytetracosanoyl-amino]-1,3,4-octadecanetriol；(2S,3S,4R)-2-[(2'R)-2'-hydroxytetracosanylamino]-1,3,4-octadecanetriol；(2S,3S,4R,2'R)-2-(2'-hydroxytetracosanoylamino)-octadecane-1,3,4-triol；(2S,3S,4R)-2-[(2R)-2-hydroxytetracosanoylamino]-1,3,4-octadecanetriol；elasticamide；ceramide；2-(2'-Hydroxytetracosanoylamino)-octadecane-1,3,4-triol, (2S,3S,4R,2'R)-；(2R)-2-hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]tetracosanamide
• CAS: 154801-30-6
• 化学式: C₄₂H₈₅NO₅
• 分子量: 684.141
• InChiKey: ZFUXWVVVWGWGPQ-QLLOZFISSA-N

物化性质

• 熔点：
  140-142 °C
• 沸点：
  799.3±60.0 °C(Predicted)
• 密度：
  0.951±0.06 g/cm3(Predicted)
• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  15.8
• 重原子数：
  48
• 可旋转键数：
  39
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.98
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  5

安全信息

• 储存条件：
  存储条件：2-8℃，干燥，密封。

制备方法与用途

Elasticamide是从弹性榕树中提取出的一种天然化合物，能够抑制U373n细胞的生长，其半数抑制浓度（IC50）为88 μM。

反应信息

• 作为反应物：
  描述：

  甲醇 、 (2S,3S,4R,2'R)-2-(2'-羟基二十四碳酰氨基)十八烷-1,3,4-三醇 在 盐酸 作用下， 反应 10.0h， 生成 methyl (2R)-2-hydroxytetracosanoate 、 糖脂
  参考文献：
  名称：

  Cytotoxic ceramides and glycerides from the roots of Livistona chinensis

  摘要：

  A 70% ethanol extract of the roots of Livistona chinensis has been investigated, led to the isolation of 13 compounds, including a new ceramide, (2S,35,4R,9Z)-2-[(2R)-2-hydroxytricosanoylamino]-9-octadecene-1,3,4-triol (2), a new glycosyl ceramide, 1-O-beta-D-glucopyranosyl-(2S,3S,4R,9Z)-2-[(2R)-2-hydroxydocosanoylamino]-9-octadecene-1,3,4-triol (3), three new monoacylglycerols, 1-(34-hydroxytetratriacontanoyl)-sn-glycerol (9), 1-[nonadeca-(9Z,12Z)-dienoyl]-sn-glycerol (10), and 1-[12-hydroxypentatriaconta-(13E,15Z)-dienoyl]-sn-glycerol (11), a new diacylglycerol, 1-(heptadeca-6Z,9Z-dienoyl)-3-(octadeca-6Z,9Z,12Z-trienoyl)-sn-glycerol (12), as well as a new diacylglycerol aminoglycoside, 1-octadecanoyl-2-nonadecanoyl-3-O-(6-amino-6-deoxy)-beta-D-glucopyranosyl-sn-glycerol (13). The structures of new compounds were elucidated. based on spectroscopic, zymologic and chemical methods. Among the compounds tested, compounds 3, 4 and 13 showed significantly antiproliferative effects against the human tumor cell lines (K562, HL-60, HepG2, and CNE-1) with the IC50 of 10-65 mu M. To our knowledge, this is first report of the occurrence of ceramides and acylglycerols in the genus Livistona. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.fitote.2012.01.008

文献信息

• Cytotoxic ceramides and glycerides from the roots of Livistona chinensis
  作者：Xiaobin Zeng、Limin Xiang、Chen-Yang Li、Yihai Wang、Guofu Qiu、Zhen-xue Zhang、Xiangjiu He

  DOI：10.1016/j.fitote.2012.01.008

  日期：2012.4

  A 70% ethanol extract of the roots of Livistona chinensis has been investigated, led to the isolation of 13 compounds, including a new ceramide, (2S,35,4R,9Z)-2-[(2R)-2-hydroxytricosanoylamino]-9-octadecene-1,3,4-triol (2), a new glycosyl ceramide, 1-O-beta-D-glucopyranosyl-(2S,3S,4R,9Z)-2-[(2R)-2-hydroxydocosanoylamino]-9-octadecene-1,3,4-triol (3), three new monoacylglycerols, 1-(34-hydroxytetratriacontanoyl)-sn-glycerol (9), 1-[nonadeca-(9Z,12Z)-dienoyl]-sn-glycerol (10), and 1-[12-hydroxypentatriaconta-(13E,15Z)-dienoyl]-sn-glycerol (11), a new diacylglycerol, 1-(heptadeca-6Z,9Z-dienoyl)-3-(octadeca-6Z,9Z,12Z-trienoyl)-sn-glycerol (12), as well as a new diacylglycerol aminoglycoside, 1-octadecanoyl-2-nonadecanoyl-3-O-(6-amino-6-deoxy)-beta-D-glucopyranosyl-sn-glycerol (13). The structures of new compounds were elucidated. based on spectroscopic, zymologic and chemical methods. Among the compounds tested, compounds 3, 4 and 13 showed significantly antiproliferative effects against the human tumor cell lines (K562, HL-60, HepG2, and CNE-1) with the IC50 of 10-65 mu M. To our knowledge, this is first report of the occurrence of ceramides and acylglycerols in the genus Livistona. (C) 2012 Elsevier B.V. All rights reserved.