(3,4-二羟基苯基)甲烷磺酸 | 79427-89-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: (3,4-二羟基苯基)甲烷磺酸
• 英文名称: (3,4-Dihydroxyphenyl)methanesulfonic acid
• CAS: 79427-89-7
• 化学式: C₇H₈O₅S
• 分子量: 204.2
• InChiKey: ONTYUVGQYZATHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• An orally administrable drug form comprising a beta-lactam antibiotic and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0036534A1

  公开（公告）日：1981-09-30

  A drug form is provided for increasing the oral absorption of β-lactam antibiotics such as the penicillins, cephalosporins and related chemical species by the oral administration of said β-lactam antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxy aryl or hydroxy aralkyl acid or salt, amide or ester thereof. The hydroxyaryl or hydroxyaralkyl acid or salt, amide or ester thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of the β-lactam antibiotic.

  本发明提供了一种药物形式，通过将β-内酰胺类抗生素口服于适当的药学上可接受的赋形剂中，并在赋形剂中加入羟基芳基或羟基芳烷基酸或其盐、酰胺或酯，从而增加β-内酰胺类抗生素如青霉素类、头孢菌素类及相关化学物质的口服吸收。羟基芳基或羟基烷基酸或其盐、酰胺或酯在药物形式中的含量足以有效提高 β-内酰胺类抗生素的口服吸收率。
• A rectally administered suppository comprising a drug and an adjuvant
  申请人：Merck & Co., Inc.

  公开号：EP0031561A2

  公开（公告）日：1981-07-08

  A drug form for enhancing the rate of absorption of a rectally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The drug form comprises a therapeutically effective dosage amount of a selected drug of the type which is capable of being absorbed into the blood stream from the rectal compartment and hydroxy aryl or hydroxy aralkyl acids or salts, amides or esters thereof, the hydroxy aryl or hydroxy aralkyl acids or salts, amides or esters thereof being present in the drug form in a sufficient amount to be effective in enhancing the drug absorption rate, when rectally administering the drug form to warm blooded animals.

  一种药物形式，用于提高直肠给药药物从直肠进入温血动物血流的吸收率。该药物剂型包括治疗有效剂量的可从直肠吸收进入血流的精选药物和羟基芳基或羟基芳烷基酸或其盐、酰胺或酯类，其中羟基芳基或羟基芳烷基酸或其盐、酰胺或酯类在药物剂型中的含量足以在给温血动物直肠给药时有效提高药物吸收率。
• An orally administered drug form comprising a glycosidic antibiotic and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0035770A2

  公开（公告）日：1981-09-16

  A drug form is provided for increasing the oral absorption of glycosidic and related antibiotics such as marcrolide, aminoglycoside, lincomycin and anthracycline antibiotics and related chemical species by the oral administration of said glycosidic and related antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaryl or hydroxyaralkyl acid or salt amide or ester thereof. The hydroxyaryl, a hydroxyaralkyl or salt amide or ester thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of glycosidic and related antibiotic.

  本发明提供了一种药物剂型，用于提高糖苷类和相关抗生素（如马克隆、氨基糖苷、林可霉素和蒽环类抗生素及相关化学物质）的口服吸收率，方法是将所述糖苷类和相关抗生素置于适当的药学上可接受的赋形剂中，并在赋形剂中添加羟基芳基或羟基烷基酸或盐酰胺或酯。 药物剂型中羟基芳基、羟基烷基或盐酰胺或酯的含量足以有效提高糖苷类和相关抗生素的口服吸收率。
• An orally administered drug form comprising a polar bioactive agent and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0036145A1

  公开（公告）日：1981-09-23

  A drug form is provided for increasing the oral absorption of polar bioactive agents such as xanthines, polyhydroxylic substances, zwitterions, polypeptides and organic anions and related chemical species by the oral administration of said polar bioactive agents in a suitable pharmaceutically accepted excipientto which has been added a hydroxyaromatic, hydroxyaryl or hydroxy aralkyl acid or salt amide or ester thereof. The hydroxy aryl or hydroxy aralkyl acid or salt amide or ester thereof is present in the drug form in quantities suffi- cientto be effective in enhancing the rate of oral absorption of the polar bioactive agents.

  本发明提供了一种药物剂型，用于增加极性生物活性剂（如黄嘌呤、多羟基物质、 齐聚物、多肽和有机阴离子及相关化学物质）的口服吸收，方法是将所述极性生物活性 剂口服在一种适当的药学上可接受的赋形剂中，在赋形剂中添加羟基芳基、羟基芳基或 羟基烷基酸或其酰胺盐或酯。羟基芳基或羟基烷基酸或其酰胺盐或酯在药物形式中的存在量足以有效提高极性生物活性剂的口服吸收率。
• US4470980A
  申请人：——

  公开号：US4470980A

  公开（公告）日：1984-09-11