syn-n-Propionaldehyd-iso-propylhydrazon | 16713-38-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: syn-n-Propionaldehyd-iso-propylhydrazon
• 英文别名: Propanal, (1-methylethyl)hydrazone；N-[(E)-propylideneamino]propan-2-amine
• CAS: 16713-38-5
• 化学式: C₆H₁₄N₂
• 分子量: 114.191
• InChiKey: XWSLKTSKRPZHPI-FNORWQNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Anti-CD123 antibodies and conjugates and derivatives thereof
  申请人：IMMUNOGEN, INC.

  公开号：US10919969B2

  公开（公告）日：2021-02-16

  The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the α chain of the interleukine 3 receptor, or IL-3Rα). The present invention also relates to methods of using such CD123-binding molecules for diagnosing and treating diseases, such as B-cell malignancies.

  本发明一般涉及与 CD123 抗原（白细胞介素 3 受体或 IL-3Rα 的 α 链）结合的抗体、其抗原结合片段、多肽和免疫结合剂。本发明还涉及使用此类 CD123 结合分子诊断和治疗疾病（如 B 细胞恶性肿瘤）的方法。
• Phosphorothioate-conjugated miRNAs and methods of using the same
  申请人：City of Hope

  公开号：US10987428B2

  公开（公告）日：2021-04-27

  Provided herein are, inter alia, nucleic acid conjugates including a non-cell penetrating ribonucleic acid compound attached at its 3′ end to a phosphorothioate polymer. Attachment of the phosphorothioate polymer to the non-cell penetrating ribonucleic acid conveys stability to and allows for efficient intracellular delivery of the non-cell penetrating ribonucleic acid. The nucleic acid conjugates provided herein including embodiments thereof are useful, inter alia, for the treatment of cancer, inflammatory disease, and pain.

  本文提供的核酸共轭物包括在其 3′端连接到硫代磷酸聚合物的非细胞穿透核糖核酸化合物。硫代磷酸酯聚合物与非细胞穿透性核糖核酸的连接为非细胞穿透性核糖核酸的细胞内输送提供了稳定性和高效性。本文提供的核酸共轭物（包括其实施方案）可用于治疗癌症、炎症性疾病和疼痛等。
• ANTI-CD123 ANTIBODIES AND CONJUGATES AND DERIVATIVES THEREOF
  申请人：IMMUNOGEN, INC.

  公开号：US20180079819A1

  公开（公告）日：2018-03-22

  The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the α chain of the interleukine 3 receptor, or IL-3Rα). The present invention also relates to methods of using such CD123-binding molecules for diagnosing and treating diseases, such as B-cell malignancies.